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- Defining the Molecular Mechanisms by Which TGF-beta Regulates T Cells
Our recent studies have established TGF-beta as an important regulator of T cell development, homeostasis, tolerance, and immunity. However, the underlying molecular mechanisms remain largely uncharacterized. - Exploring the Cellular Mechanisms by Which TGF-beta1 Regulates T Cells
Development of TGF-beta1 conditional knockout mouse model enables the study of cell type-specific functions of TGF-beta1 in vivo. We have found that T cell-produced TGF-beta1 is essential for T cell tolerance and immunity. - TGF-beta Regulation of T Cell Responses in Autoimmune Diseases
Colitis is a digestive disease characterized by inflammation of the colon. Development of colitis in T cell-specific TGF-beta1-deficient mice reveals an important function for TGF-beta1 in mucosal immune tolerance. Colitis in these mice is likely caused by abnormal immune responses to commensal bacterial antigens. - TGF-beta Regulation of T Cell Responses in Cancer
Understanding the interactions between tumor cells and the immune system is of interest not only for elucidating cancer mechanisms but also for immunotherapy of cancer. Since tumors are derived from normal self tissues, the default pathway to tumor antigens is likely tolerance. Therefore, it will be essential to remove the self-tolerance checkpoints to enhance tumor immunity.
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