Major Research Areas

Publications

Huse, M.*, Klein, L. O.*, Girvin, A. T., Faraj, J. M., Li, Q., Kuhns, M. S., and Davis, M. M. (2007). Spatial and Temporal Dynamics of T Cell Receptor Signaling with a Photocaged Agonist. Immunity, 27, 76-88 *equal contribution

Davis, M. M., Krogsgaard, M., Huse, M., Huppa, J., Lillemeier, B. F., and Li, Q.-J. (2007). T Cells as a Self-Referential, Sensory Organ. Annu. Rev. Immunol. 25, 681-695

Huse, M., Lillemeier, B. F., Kuhns, M. S., Chen, D. S., and Davis, M. M. (2006). T Cells Use Two Directionally Distinct Pathways for Cytokine Secretion. Nat. Immunol. 7, 247-255.

Krogsgaard, M., Li, Q.-J., Sumen, C., Huppa, J. B., Huse, M., and Davis, M. M. (2005). Agonist/Self Peptide-MHC Heterodimers Drive T Cell Activation and Sensitivity. Nature 434, 238-243

Ottesen J. J., Huse, M., Sekedat, M. D., and Muir, T. W. (2004). Semisynthesis of Phosphovariants of Smad2 Reveals a Substrate Preference for the Activated TbetaR-I Kinase. Biochemistry 43, 5698-5706.

Huse, M. and Kuriyan, J. (2002). The Conformational Plasticity of Protein Kinases. Cell 109, 275-282.

Huse, M. (2002). Structural Biology: Alive and Skiing. Structure 10, 137-138.

Flavell, R. R., Huse, M., Goger, M., Trester-Zedlitz, M., Kuriyan, J., and Muir, T. W. (2002). Efficient Semi-synthesis of a Tetraphosphorylated Analog of the Type I TGF-beta Receptor. Org. Lett.4,165-168.

Wu, J.-W., Hu, M., Chai, J., Seoane, J., Huse, M., Li, C., Rigotti, D. J., Kyin, S., Muir, T. W., Fairman, R., Massagué, J., and Shi, Y. (2001). Crystal Structure of Phosphorylated Smad2: Recognition of Phosphoserine by the MH2 Domain and Insights on Smad Function in TGF-beta Signaling. Mol. Cell 8, 1277-1289.

Huse, M., Muir, T. W., Xu, L., Chen, Y.-G., Kuriyan, J., and Massagué, J. (2001). The TGF-beta Receptor Activation Process: An Inhibitor- to Substrate-binding Switch. Mol. Cell 8, 671-682.

Huse, M., Holford, M. N., Kuriyan J., and Muir, T. W. (2000). Semi-synthesis of Hyperphosphorylated Type I TGF-beta Receptor: Addressing the Mechanism of Kinase Activation. J. Am. Chem Soc. 122, 8337-8338

Huse, M., Chen, Y. G., Massagué, J., and Kuriyan, J. (1999). Crystal Structure of the Cytoplasmic Domain of the Type I TGF-beta Receptor in Complex with FKBP12. Cell 96, 425-436.

Huse, M., Eck, M. J., and Harrison, S. C. (1998). A Zn2+ Ion Links the Cytoplasmic Tail of CD4 to the N-terminal region of Lck. J. Biol. Chem. 273, 18729-18733.

Moarefi, I., LaFevre-Bernt, M., Sicheri, F., Huse, M., Lee, C.-H., Kuriyan, J., and Miller, W. T. (1997). Activation of the Src-family Tyrosine Kinase Hck by SH3 Domain Displacement. Nature 385, 650-653.

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