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Human Oncology and Pathogenesis Program

Timothy A. Chan

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Ingo K. Mellinghoff

Charles L. Sawyers

Publications

Peer-Reviewed Articles

Timothy A. Chan, Heiko Hermeking, Christoph Lengauer, Kenneth W. Kinzler, and Bert Vogelstein (1999) 14-3-3ó is required to prevent mitotic catastrophe following DNA damage. Nature 401, 616-620. (featured article in News & Views)

Tong-chuan He, Timothy A. Chan, Bert Vogelstein, and Kenneth W. Kinzler (1999)PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell 99, 335-345.

Timothy A. Chan, Paul M. Hwang, Heiko Hermeking, Kenneth W. Kinzler, and Bert Vogelstein (2002) Cooperative effects of genes controlling the G2/M checkpoint. Genes and Development 14, 1584-1588.

Timothy A. Chan, Sabine Glockner, Joo Mi Yi, Wei Chen, Leander Van Neste, Leslie Cope, James G. Herman, Victor Velculescu, Kornel E. Schuebel, Nita Ahuja, Stephen B. Baylin (2008) Convergence of Mutation and Epigenetic Alterations Identifies Common Genes in Cancer that Predict for Poor Prognosis. PLoS Medicine 5 (5).

Timothy A. Chan (2002) Nonsteroidal anti-inflammatory drugs, apoptosis, and colon cancer chemoprevention. Lancet Oncology 3, 166-174.

Timothy A. Chan, Zhenghe Wang, Long H. Dang, Bert Vogelstein, and Kenneth W. Kinzler (2002) Targeted inactivation of CTNNB1 reveals unexpected effects of beta-catenin mutation. Proceedings of the National Academy of Sciences USA 99, 8265-8270.

Timothy A. Chan (2003) Cyclooxygenase inhibition and mechanisms of colorectal cancer prevention. Curr. Cancer Drug Targets 3, 455-63.

Timothy A. Chan, Jon D. Weingart, Michele Parisi, Michael H. Hughes, Alessandro Olivi, Scott Borzillary, Dineli Alahakone, Nicholas A. Detorie, Moody D. Wharam, and Lawrence Kleinberg (2005) Treatment of recurrent glioblastoma multiforme with GliaSite brachytherapy. International Journal of Radiation Oncology, Biology, Physics 62, 1131139.

Timothy A. Chan (2006) Prostaglandins and the Colon Cancer Connection. Trends in Molecular Medicine 12, 240-244.

Timothy A. Chan*, Patrice J. Morin*, Bert Vogelstein, and Kenneth W. Kinzler (1998) Mechanisms underlying nonsteroidal anti-inflammatory drug-induced apoptosis. Proceedings of the National Academy of Sciences USA 95, 681-686.

Timothy Chan (1992) Structure and function of Hydra tyrosine kinase proto oncogenes. BASE 8, 18-28.

Timothy A. Chan, Christian A. Chu, Katheine A. Rauen, Michael Kroiher, Suzanna M. Tatarewicz, and Robert E. Steele (1994) Identification of a gene encoding a novel protein tyrosine kinase containing SH2 domains and ankyrin repeats. Oncogene 9, 1253-1259.

Kornel E. Schuebel, Wei E. Chen, Leslie Cope, Sabine Glockner, Hiromo Suzuki, JooMi Yi, Timothy A. Chan, Leander Van Neste, W. Van Criekinge, et al. (2007). Comparing the DNA hypermethalome with gene mutations in human colorectal cancer. PLoS Genetics 3, 1709-1723.

Paul M. Hwang, Fred Bunz, Jian Yu, Carlo Rago, Timothy A. Chan, Michael P. Murphy, Geoffry F. Kelso, Robin A.J. Smith, Kenneth W. Kinzler, and Bert Vogelstein (2001) Ferredoxin reductase affects p53-dependent, 5-fluorouracil induced apoptosis in colorectal cancer cells. Nature Medicine 7, 1111-1117.

A.T. Ferguson, E. Evron, C.B. Umbricht, T.K. Pandita, Timothy A. Chan, Heiko Hermeking, J.R. Marks, A.R. Lambers, P.A. Futreal, M.R. Stampfer, and Saraswati Sukumar (2000) High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer. Proceedings of the National Academy of Sciences USA 97, 6049-6054.

Hiroyuki Suzuki, Xiaoling Zhou, Jing Yin, Junyi Lei, Hai Yan Jiang, Yukiko Suzuki, Tim Chan, Gregory J. Hannon, Wolfgang J. Mergner, John M. Abraham, and Steven J. Meltzer (1995) Intragenic mutations of CDKN2B and CDKN2A in primary human esophageal cancers. Human Molecular Genetics 4, 1883-1887.

Xiaoling Zhou, Hiroyuki Suzuki, Junyi Lei, Kristina Cole, Jing Yin, Yukiko Suzuki, John M. Abraham, Yutaka Shimada, Masayuki Imamura, Tim Chan, Gregory J. Hannon, and Stephen J. Meltzer (1996) Growth Suppression of Esophageal Cancer Cells by p16INK4 and p15INK4B in vitro. Cancer J. Sci. Am. 2, 221-225.

Luis T. daCosta, Jin Jen, Tong-chuan He, Timothy A. Chan, Kenneth W. Kinzler, and Bert Vogelstein (1996) Converting cancer genes into killer genes. Proceedings of the National Academy of Sciences USA 93, 4192-4196.

Kohtaro Takei, Timothy A. Chan, Feng-Song Wang, Haiyan Deng, Urs Rutishauser, and Daniel G. Jay (1999) The neural cell adhesion molecules L1 and NCAM-180 act in different steps of neurite outgrowth. The Journal of Neuroscience 19, 9469-9479.

David E. Gerber, Stuart A. Grossman, Timothy A. Chan, and Lawrence E. Kleinberg (2007) Intracranial hemorrhage during GliaSite RTS in a patient receiving anticoagulation. The Journal of Radiotherapy in Practice 6, 53-57.

Chan TA, Collis SJ, Schwaninger JM, DeWeese TL. Elevated mutation frequency in cells heterozygous for Msh2. (submitted)

Lawrence Kleinberg, Geoffrey Yoon, Jon D. Weingart, Michelle Parisi, Alessandro Olivi, Nick A. Detorie, and Timothy A. Chan (2009) Imaging After GliaSite Brachytherapy: Prognostic MRI Indicators of Disease Control and Recurrence. Int J. Radiat Oncol Bio Phys. April 23, 2009.

Wong, J., Armour, E., Kazanzides, P., Iordachita, I., Tryggestad, E., Deng, H., Matinfar, M. Kennedy, C., Liu, Z., Chan T., Gray, O., Verhaegen, F., McNutt, T., DeWeese, TL. (2008) High-resolution, small animal radiation research platform with x-ray tomographic guidance capabilities. Int J Radiat Oncol Biol Phys. 71 (5) 1591-9.

Gerber DE, Chan TA. Recent advances in radiation therapy. Am Fam Physician. 2008 Dec 1;78(11):1254-62.

Glöckner SC, Dhir M, Yi JM, McGarvey KE, Van Neste L, Louwagie J, Chan TA, Kleeberger W, de Bruïne AP, Smits KM, Khalid-de Bakker CA, Jonkers DM, Stockbrügger RW, Meijer GA, Oort FA, Iacobuzio-Donahue C, Bierau K, Herman JG, Baylin SB, Van Engeland M, Schuebel KE, Ahuja N. Methylation of TFPI2 in Stool DNA: A Potential Novel Biomarker for the Detection of Colorectal Cancer. Cancer Res. 2009 May 12. [Epub ahead of print]

Veeriah S, Brennan C, Meng S, Singh B, Fagin JA, Solit DB, Paty PB, Rohle D, Vivanco I, Chmielecki J, Pao W, Ladanyi M, Gerald WL, Liau L, Cloughesy TC, Mischel PS, Sander C, Taylor B, Schultz N, Major J, Heguy A, Fang F, Mellinghoff IK, Chan TA. The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers. Proceedings of the National Academy of Science USA 2009.

Meng S, Arbit T, Veeriah S, Mellinghoff IK, Fang F, Vivanco I, Rohle D, Chan TA. 14-3-3sigma and p21 synergize to determine DNA damage response following Chk2 inhibition. Cell Cycle. 2009 Jul 12;8(14). [Epub ahead of print]

Chan TA and Heguy A. The protein tyrosine phosphatase D, a broadly inactivated tumor suppressor regulating STAT function. Cell Cycle 2009, 8(19).

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