Here is a list of research papers that have been presented for discussion in our weekly group meetings. Papers are selected by group members as a means to broaden our knowledge in chemistry and chemical biology.
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10 Nov 2008, presented by Guodong Liu
A concise asymmetric total synthesis of aspidophytine.
Nicolaou, K. C.*; Dalby, S. M.; Majumder, U. J. Am. Chem. Soc. 2008, 130, 14942–14943.
[ Abstract | PDF | Supporting Info ]
27 Oct 2008, presented by Justin Cisar
Targeted polypharmacology: Discovery of dual inhibitors of tyrosine and phosphoinositide kinases.
Apsel, B.; Blair, J. A.; Gonzalez, B.; Nazif, T. M.; Feldman, M. E.; Aizenstein, B.; Hoffman, R.; Williams, R. L.; Shokat, K. M.*; Knight, Z. A. Nat. Chem. Biol. 2008, 4, 691–699.
[ Abstract | PDF | Supporting Info ]
29 Sep 2008, presented by Chris Stratton
Ligand-binding pocket shape differences between sphingosine 1-phosphate (S1P) receptors S1P1 and S1P3 determine efficiency of chemical probe identification by ultrahigh-throughput screening.
Schürer, S. C; Brown, S. J.; Gonzalez-Cabrera, P. J.; Schaeffer, M.-T.; Chapman, J.; Jo, E.; Chase, P.; Spicer, T.; Hodder, P.; Rosen, H* ACS Chem. Biol. 2008, 3, 486–498.
[ Abstract | PDF | Supporting Info ]
19 Aug 2008, presented by Jackie Wurst
Biomimetic synthesis of the IDO inhibitors exiguamine A and B.
Volgraf, M; Lumb, J.-P.; Brastianos, H. C.; Carr, G. ;Chung, M. K. W.; Münzel, M.; Mauk, A. G.; Andersen, R. J.*; Trauner, D.* Nat. Chem. Biol. 2008, 4, 535–537.
[ Abstract | PDF | Supporting Info ]
11 Aug 2008, presented by Shalini Balakrishnan
Targeted rescue of a destabilized mutant of p53 by an in silico screened drug.
Boecker, F. M.; Joerger, A. C.; Jaggi, G.; Rutherford, T. J.; Veprintsev, D. B.; Fersht, A. R.* Proc. Natl. Acad. Sci. USA 2008, 105, 10360–10365.
[ Abstract | PDF | Supporting Info ]
28 Jul 2008, presented by Renato Bauer
Disparate proteome reactivity profiles of carbon electrophiles.
Weerapana, E.; Simon, G. M.; Cravatt, B. F.* Nat. Chem. Biol. 2008, 4, 405–407.
[ Abstract | PDF | Supporting Info ]
30 Jun 2008, presented by Xuequan Lu
Structure-based design of an organoruthenium phosphatidyl-inositol-3-kinase inhibitor reveals a switch governing lipid kinase potency and selectivity.
Xie, P.; Williams, D. S.; Atilla-Gokcumen, G. E.; Milk, L.; Xiao, M.; Smalley, K. S.; Herlyn, M.; Meggers, E.; Marmorstein, R.* ACS Chem. Biol. 2008, 3, 305–316.
[ Abstract | PDF | Supporting Info ]
26 May 2008, presented by Felix Kopp
Nickel-catalyzed cross-coupling of aryl methyl ethers with aryl boronic esters.
Tobisu, M.; Shimasaki, T.; Chatani, N.* Angew. Chem. Intl. Ed. 2008, 47, 4866–4869.
[ Abstract | PDF | Supporting Info ]
19 May 2008, presented by Guodong Liu
Catalytic asymmetric Michael reactions of acetaldehyde.
García-García, P.; Ladépêche, A.; Halder, R.; List, B.* Angew. Chem. Intl. Ed. 2008, 47, 4719–4721.
[ Abstract | PDF | Supporting Info ]
Asymmetric Michael reaction of acetaldehyde catalyzed by diphenylprolinol silyl ether.
Hayashi, Y.*, Itoh, T.; Ohkubo, M.; Ishikawa, H. Angew. Chem. Intl. Ed. 2008, 47, 4722–4724.
[ Abstract | PDF | Supporting Info ]
5 May 2008, presented by Justin Cisar
Cysteine-free peptide and glycopeptide ligation by direct aminolysis.
Payne, R. J.; Ficht, S.; Greenberg, W. A.; Wong, C.-H.* Angew. Chem. Intl. Ed. 2008, 47, 4411–4415.
[ Abstract | PDF | Supporting Info ]
28 Apr 2008, presented by Christopher Stratton
Synthesis of 1,9-dideoxy-pre-axinellamine.
Yamaguchi, J.; Seiple, I. B.; Young, I. S.; O'Malley, D. P.; Maue, M.; Baran, P. S.* Angew. Chem. Intl. Ed. 2008, 47, 3578–3580.
[ Abstract | PDF | Supporting Info ]
Total synthesis of (±)-axinellamines A and B.
O'Malley, D. P.; Yamaguchi, J.; Young, I. S.; Seiple, I. B.; Baran, P. S.* Angew. Chem. Intl. Ed. 2008, 47, 3581–3583.
[ Abstract | PDF | Supporting Info ]
21 Apr 2008, presented by Shalini Balakrishnan
Using engineered scaffold interactions to reshape MAP kinase pathway signaling dynamics.
Bashor, C. J.; Helman, N. C.; Yan, S.; Lim, W. A.* Science 2008, 319, 1539–1543.
[ Abstract | PDF | Supporting Info ]
31 Mar 2008, presented by Jacqueline Wurst
Anti-MRSA agent discovery using diversity-oriented synthesis.
Thomas, G. L.; Spandl, R. J.; Glandsorp, F. G.; Welch, M.; Bender, A.; Cockfield, J.; Lindsay, J. A.; Bryant, C.; Brown, D. F. J.; Loiseleur, O.; Rudyk, H.; Ladlow, M.; Spring, D. R.* Angew. Chem. Intl. Ed. 208, 47, 2808–2812.
[ Abstract | PDF | Supporting Info ]
17 Mar 2008, presented by Renato Bauer
Stereoretentive synthesis and chemoselective amide-forming ligations of C–terminal peptide α–ketoacids.
Ju, L.; Lippert, A. R.; Bode, J. W* J. Am. Chem. Soc. 2008, 130, 4253–4255.
[ Abstract | PDF | Supporting Info ]
3 Mar 2008, presented by Xuequan Lu
Catalytic C–H functionalization by metal carbenoid and nitrenoid insertion.
Davies, H. M. L.*; Manning, J. R. Nature 2008, 451, 417–424.
[ Abstract | PDF ]
11 Feb 2008, presented by Christine DiBlasi
Negative regulation of the deacetylase SIRT1 by DBC1.
Zhao, W.; Kruse, J.-P.; Tang, Y.; Jung, S. Y.; Qin, J.; Gu, W.* Nature 2008, 451, 587–590.
[ Abstract | PDF | Supporting Info ]
28 Jan 2008, presented by Felix Kopp
Oxidative cross-coupling of arenes induced by single-electron transfer leading to biaryls by use of organoiodine(III) oxidants.
Dohi, T.; Ito, M.; Morimoto, K.; Iwata, M.; Kita, Y.* Angew. Chem., Intl. Ed. 2008, 47, 1301–1304.
[ Abstract | PDF | Supporting Info ]
15 Jan 2008, presented by Guodong Liu
A predictably selective aliphatic C-H oxidation reaction for complex molecule synthesis.
Chen, M. S.; White, M. C.* Science 2007, 318, 783–787.
[ Abstract | PDF | Supporting Info ]
08 Jan 2008, presented by Justin Cisar
Glycan topology determines human adaptation of avian H5N1 virus hemagglutinin.
Chandrasekaran, A.; Srinivasan, A.; Raman, R.; Viswanathan, K.; Raguram, S.; Tumpey, T. M.; Sasisekharan, V.; Sasisekharan, R* Nat. Biotechnol. 2008, 26, 107–113.
[ Abstract | PDF | Supporting Info ]
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