Polarized cell migration is characteristic of many important biological processes, for example wound healing, embryonic development or chemotaxis. I am interested in the signaling pathways regulating cell polarization, using wound-healing assays in cultured fibroblasts and epithelial cells. In an earlier work we found that Wnt5a was important for centrosome reorientation, an early step in cell polarization, and that dishevelled (Dvl) and axin, two key Wnt-signaling molecules, were also required for this pathway. I am currently investigating the mechanism by which Wnt5a is regulating polarized cell migration and the potential link between Wnt5a/Dvl the previously characterized pathway, controlled by Cdc42/aPKC.