Major Research Areas

Publications

Lu L-F, Tai T-H, Calado DP, Chaudhry A, Loeb GB, Rajewsky A, Rudensky AY. (2009) Foxp3-dependent regulation of microRNA 155 maintains regulatory T cell homeostasis. Immunity 30: 80-91.

Zheng Y, Chaudry A, Kas A, deRoos P, Kim J, Treuting P, Klen U, Rudensky AY. (2008) Regulatory T cell suppressor program co-opts transcription factor IRF4 to control Th2 responses. Nature (01 Feb 2009), doi: 10.1038/nature07674.

Liston A, Lu L-F, O'Carroll D, Tarakhovsky A, Rudensky AY. (2008) Dicer-dependent microRNA pathway safeguards regulatory T cell function. J Exp Med. 205(9):1993-2004

Lund JM, Hsing L, Pham TT, Rudensky AY. (2008) Coordination of early protective immunity to viral infection by regulatory T cells. Science (2008) 320:1220-4. Epub Apr 24.

Rubtsov YP, Rasmussen JP, Chi EY, Fontenot J, Castelli L, Ye X, Treuting P, Siewe L, Roers A, Henderson WR Jr, Muller W, Rudensky AY. (2008) Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity 28: 546-558.

Liston A, Farr AG, Chen Z, Mathis D, Benoist C, Manley NR, Rudensky AY. 2007. Lack of Foxp3 function and expression in the thymic epithelium. J Exp Med 204:475-480.

Zheng Y, Josefowicz SZ, Kas A, Chu TT, Gavin MA, Rudensky AY. (2007) Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells. Nature, 445:936-940.

Williams LM, Rudensky AY. 2007. Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells required continued expression of Foxp3. Nature Immunol, 8:277-284.

Gavin MA, Rasmussen JP, Fontenot JD, Vasta V, Manganiello VC, Beavo JA, Rudensky AY. (2007) Foxp3-dependent programme of regulatory T-cell differentiation. Nature, 445:77.

Kim J, Rasmussen J, Rudensky AY. 2007. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nature Immunol 8:191-7.

Marie JC, Liggitt, D, Rudensky AY. 2006. Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity 25 (3): 441-54.

Hsieh CS, Zheng Y, Liang Y, Fontenot JD, Rudensky AY. 2006. An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. Nature Immunol. 2006. 7:401-10.

Fontenot JD, Rasmussen JP, Gavin MA, Rudensky AY. 2005. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nature Immunol 6:1142-1151.

Fontenot JD, Dooley JL, Farr AG, Rudensky AY. 2005. Developmental regulation of Foxp3 expression during ontogeny. J Exp Med 202:901-906.

Marie JC, Letterio JJ, Gavin M, Rudensky AY. (2005). TGF-b1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells. J Exp Med. 201:1061-1067.

Fontenot JD, Rasmussen JP, Williams LM, Dooley JL, Farr AG, Rudensky AY. (2005). Regulatory T cell lineage specification by the forkhead transcription factor Foxp3. Immunity. 22:329-341.

Hsieh C S, Liang Y, Tyznik A, Self SG, Liggitt D, A. Rudensky. (2004). Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors. Immunity 21:267-277.

Fontenot JD, Gavin MA, Rudensky AY. 2003. Foxp3 programs the development and function of CD4+ CD25+ regulatory T cells. Nature Immunol 4:330-336.

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