I am interested in understanding how organs develop their 3-dimensional, functional organization. This development requires the generation of the correct number of cells, specification of these cells into different identities, their appropriate arrangement and, in the case of the nervous system, establishment of connections to communicate with cells often great distances away. I address these issues using the cerebellum, a region of the brain whose complex morphology likely contributes to successful motor information processing. The cerebellum is organized along the antero-posterior axis in a series of folia and along the medial-laterial axis in parasagittal molecular domains. My work focuses on better understanding how this organization arises and its functional significance.
