Here is a list of research papers that have been presented for discussion in our weekly group meetings. Papers are selected by group members as a means to broaden our knowledge in chemistry and chemical biology.
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9 Nov 2009, presented by Debarshi Pratihar
Enantiodivergent conversion of chiral secondary alcohols into tertiary alcohols.
Stymiest, J. L.; Bagutski, V.; French, R. M.; Aggarwal, V. K.* Nature 2008, 456, 778–782.
[ Abstract | PDF | Supporting Info ]
26 Oct 2009, presented by Gustavo Moura-Letts
Iron-catalyzed C(sp³)–C(sp³) bond formation through C(sp³)–H functionalization: A cross-coupling reaction of alcohols with alkenes.
Zhang, S.-Y.; Tu, Y.-Q.; Fan, C.-A.; Zhang, F.-M.; Shi, L.* Angew. Chem. Intl. Ed. 2009, 48, 8761–8765.
[ Abstract | PDF | Supporting Info ]
5 Oct 2009, presented by Chris Stratton
Synthetic study toward the total synthesis of maoecrystal V.
Gong, J.; Lin, G.; Li, C.-c.*; Yang, Z.* Org. Lett. 2009, 11, in press.
[ Abstract | PDF | Supporting Info ]
A synthesis of the carbon skeleton of maoecrystal V.
Krawczuk, P. J.; Schöne, N.; Baran, P. S.* Org. Lett. 2009, 11, in press.
[ Abstract | PDF | Supporting Info ]
23 Sep 2009, presented by Shalini Balakrishnan
A chemical screen for biological small molecule-RNA conjugates reveals CoA-linked RNA.
Kowtoniuk, W. E.; Shen, Y.; Heemstra, J. M.; Agarwal, I.; Liu, D. R.* Proc. Natl. Acad. Sci. USA 2009, 106, 7768–7773.
[ Abstract | PDF | Supporting Info ]
16 Sep 2009, presented by Jackie Wurst
Can one predict changes from SN1 to SN2 mechanisms?
Phan, T. B.; Nolte, C.; Kobayashi, S.; Ofial, A.R.; Mayr, H.* J. Am. Chem. Soc. 2009, 131, 11392–11401.
[ Abstract | PDF | Supporting Info ]
10 Aug 2009, presented by Renato Bauer
Quantifying biogenic bias in screening libraries.
Hert, J.; Irwin, J. J.; Laggner, C.; Keiser, M. J.; Shoichet, B. K.* Nat. Chem. Biol. 2009, 5, 479–483.
[ Abstract | PDF | Supporting Info ]
22 Jul 2009, presented by Xuequan Lu
Synthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibition.
Clerc, J.; Groll, M.; Illich, D. J.; Bachmann, A. S.; Huber, R.; Schellenberg, B.; Dudler, R.*; Kaiser, M.* Proc. Natl. Acad. Sci. USA 2009, 106, 6507–6512.
[ Abstract | PDF | Supporting Info ]
13 Jul 2009, presented by Felix Kopp
Radicals and transition-metal catalysis - An alliance par excellence to increase reactivity and selectivity in organic chemistry.
Ford, L.; Jahn, U.* Angew. Chem. Intl. Ed. 2009, 48, 6386–6389.
[ Abstract | PDF ]
29 June 2009, presented by Guodong Liu
Biosynthesis and metabolism of cyclopropane rings in natural compounds.
Wessjohann, L. A.*; Brandt, W. Chem. Rev. 2003, 103, 1625–1647.
[ Abstract | PDF ]
2 June 2009, presented by Tony Davis
A small molecule that binds Hedgehog and blocks its signaling in human cells.
Stanton, B. Z.; Peng, L. F.*; Maloof, N.; Nakai, K.; Wang, X.; Duffner, J. L.; Taveras, K. M.; Hyman, J. M.; Lee, S. W.; Koehler, A. N.; Chen, J, K.; Fox, J. L.; Mandinova, A.; Schreiber, S. L.* Nat. Chem. Biol. 2009, 5, 154–156.
[ Abstract | PDF | Supporting Info ]
18 May 2009, presented by Debarshi Pratihar
Achieving molecular complexity by organocatalytic one-pot strategies - A fast entry for synthesis of sphingoids, amino sugars, and polyhydroxylated α-amino acids.
Jiang, H.; Elsner, P.; Jensen, K. L.; Falcicchio, A.; Marcos, V.; Jørgensen, K. A.* Angew. Chem. Intl. Ed. 2009, 48, 6844–6848.
[ Abstract | PDF | Supporting Info ]
27 April 2009, presented by Gustavo Moura-Letts
How protein recognizes ladder-like polycyclic ethers: Interactions between ciguatoxin (CTX3C) fragments and its specific antibody 10C9.
Ui, M.; Tanaka, Y.; Tsumuraya, T.; Fujii, I.; Inoue, M.; Hirama, M.; Tsumoto, K.* J. Biol. Chem. 2008, 283, 19440–19447.
[ Abstract | PDF | Supporting Info ]
13 April 2009, presented by Chris Stratton
Identification of a chemical probe for NAADP by virtual screening.
Naylor, E.; Arredouani, A.; Vasudevan, S. R.; Lewis, A. M.; Parkesh, R.; Mizote, A.; Rosen, D.; Thomas, J. M.; Izumi, M.; Ganesan, A.; Galione, A.; Churchill, G. C.* Nat. Chem. Biol. 2009, 5, 220–226.
[ Abstract | PDF | Supporting Info ]
30 Mar 2009, presented by Shalini Balakrishnan
Dynamic proteomics of individual cancer cells in response to a drug.
Cohen, A. A.*; Geva-Zatorsky, N.; Eden, E.; Frenkel–Morgenstern, M.; Issaeva, I.; Sigal, A.; Milo, R.; Cohen–Saidon, C.; Liron, Y.; Kam, Z.; Cohen, L.; Danon, T.; Perzov, N.; Alon, U. Science 2008, 322, 1511–1516.
[ Abstract | PDF | Supporting Info ]
9 Mar 2009, presented by Jackie Wurst
Total synthesis of a chlorosulpholipid cytotoxin associated with seafood poisoning.
Nilewski, C.; Geisser, R. W.; Carreira, E. M.* Nature 2009, 457, 573–576.
[ Abstract | PDF | Supporting Info ]
19 Jan 2009, presented by Renato Bauer
Self-consistent synthesis of the squalene synthase inhibitor zaragozic acid C via controlled oligomerization.
Nicewicz, D. A.; Satterfield, A. D.; Schmitt, D. C.; Johnson, J. S.* J. Am. Chem. Soc. 2008, 130, 17281–17283.
[ Abstract | PDF | Supporting Info ]
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