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- Using molecular biology and biochemical approaches to find out why proximal polyadenylation signals are being ignored in normal cells but being recognized and used in stem cells and cancer cells.
- Using genomic approaches to learn about the consequences of APA.
- To identify regulatory elements other than miRNAs in 3'UTRs.
- To identify cancer subtypes, conditions and signaling pathways that influence 3' end formation of mRNAs using cell culture and cell biology methods.
- To learn if shorter 3'UTRs are a cause or a consequence of oncogenic transformation applying mouse genetics.
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