Major Research Areas

Publications

Mayr C, Bartel DP. Widespread shortening of 3'UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells. Cell, in press.

Wang ET, Sandberg R, Luo S, Khrebtukova I, Zhang L, Mayr C, Kingsmore SF, Schroth GP, Burge CB. Alternative isoform regulation in human tissue transcriptomes. Nature 456, 470-476 (2008). Epub 2008 Nov 2.

Wiesner M, Zentz C, Mayr C, Wimmer R, Hammerschmidt W, Zeidler R, Moosmann A. Conditional immortalization of human B cells by CD40 ligation. PloS ONE 3, e1464 (2008).

Bund D, Mayr C, Kofler DM, Hallek M, Wendtner CM. CD23 is recognized as tumor-associated antigen (TAA) in B-CLL by CD8+ autologous T lymphocytes. Exp Hematol 35, 920-930 (2007).

Zhou B, Wang S, Mayr C, Bartel DP, Lodish HF. miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely. Proc Natl Acad Sci U S A 104, 7080-7085 (2007). Epub 2007 Apr 16.

Mayr C, Hemann MT, Bartel DP. Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation. Science 315, 1576-1579 (2007). Epub 2007 Feb 22.

Bund D, Mayr C, Kofler DM, Hallek M, Wendtner CM. Human Ly9 (CD229) as novel tumor-associated antigen (TAA) in chronic lymphocytic leukemia (B-CLL) recognized by autologous CD8+ T cells. Exp Hematol 34, 860-869 (2006).

Mayr C, Bund D, Schlee M, Bamberger M, Kofler DM, Hallek M, Wendtner CM. MDM2 is recognized as a tumor-associated antigen in chronic lymphocytic leukemia by CD8+ autologous T lymphocytes. Exp Hematol 34, 44-53 (2006).

Mayr C, Speicher MR, Kofler DM, Buhmann R, Busch R, Strehl J, Hallek M, Wendtner CM. Chromosomal translocations are associated with poor prognosis in chronic lymphocytic leukemia. Blood 107, 742-751 (2006). Epub 2005 Sep 22.

Mayr C, Kofler DM, Büning H, Bund D, Hallek M, Wendtner C-M. Transduction of CLL cells by CD40 ligand (CD40L) enhances an antigen specific immune recognition by autologous T cells. Blood 106, 3223-3226 (2005). Epub 2005 Jul 12.

Mayr C, Bund D, Schlee M, Moosmann A, Kofler DM, Hallek M, Wendtner C-M. Fibromodulin as a novel tumor-associated antigen (TAA) in chronic lymphocytic leukemia (CLL) which allows expansion of specific CD8+ autologous T lymphocytes. Blood 105, 1566-1573 (2005). Epub 2004 Oct 7.

Kofler DM, Büning H, Mayr C, Bund D, Baumert J, Hallek M, Wendtner CM. Engagement of the B-cell antigen receptor (BCR) allows efficient transduction of ZAP-70 positive B-CLL cells by recombinant adeno-associated virus (rAAV) vectors. Gene Ther 11, 1416-1424 (2004).

Wendtner CM, Kofler DM, Mayr C, Bund D, Hallek M. The potential of gene transfer into primary B-CLL cells using recombinant virus vectors. Leuk Lymphoma 45, 897-904 (2004).

Strehl J, Mey U, Glasmacher A, Djulbegovic B, Mayr C, Gorschluter M, Ziske C, Schmidt-Wolf IG. High-dose chemotherapy followed by autologous stem cell transplantation as first-line therapy in aggressive non-Hodgkin's lymphoma is superior to conventional chemotherapy in selected patients: a meta-analysis. Haematologica 88, 1304-1315 (2003).

Mayr C, Radzom S, Dreyling M. Neurotoxicity under chemotherapy with high doses of cytarabin. Arzneimitteltherapie 19, 296-298 (2001).

Hildebrandt M, Rose M, Mayr C, Arck P, Schüler C, Reutter W, Salama A, Klapp BF. Dipeptidyl peptidase IV (DPP IV, CD 26) in patients with mental eating disorders. Adv Exp Med Biol 477, 197-204 (2000).

Hildebrandt M, Rose M, Mayr C, Schüler C, Reutter W, Salama A, Klapp BF. Alterations in expression and in serum activity of dipeptidyl peptidase IV (DPP IV, CD 26) in patients with hyporectic eating disorders. Scand J Immunol 50, 536-541 (1999).

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