Also Known As: VP-16-(IV), Vepesid®-(IV)
Etoposide prevents cancer cells from growing by interfering with DNA, the genetic material in cells.
How It Is Given:
Intravenously (by vein)
Immediate Side Effects (beginning within 24 hours):
- A metallic taste can develop while you are receiving the drug and last for a short time.
- Mild nausea or loss of appetite can occur and last for one to two days.
- Facial flushing can develop during the infusion.
- Allergic reactions can occur, but they are rare.
- Low blood pressure may occur while you are receiving the drug.
Early Side Effect (beginning within the first week):
- Mouth sores can develop within four to seven days.
Late Side Effects (beginning after one week):
- A temporary decrease in blood cell counts-- white blood cells and platelets--may occur within one to two weeks after treatment.
- Temporary thinning or loss of hair can begin within two to three weeks after treatment.
- Numbness and tingling in hands and feet may occur after several treatments.
Special Points:
- Sucking hard candy during treatment may lessen the metallic taste.
- Do not take aspirin, ibuprofen (e.g., Motrin®, Advil®), or products containing them unless your doctor prescribes them.
- Tell your doctor or nurse if you are taking any other medications, including over-the-counter preparations that do not require a prescription, herbal remedies, vitamins, or dietary supplements. Some of these may interfere with your chemotherapy.
Call Your Doctor or Nurse If You Have:
- A fever of 100.5° F (38° C) or higher.
- Excessive vomiting and are unable to eat or drink for 24 hours.
- Black bowel movements, bruising, a faint red rash, or any other signs of bleeding.
- Mouth sores that prevent you from eating or drinking.
- Any unexplained or unexpected problems.
- Any questions or concerns.
