Also Known As: Doxil®
Doxorubicin (docks-a-RU-bi-sin) is a liposomal form of doxorubicin (Adriamycin®), a drug that prevents cancer cells from growing by attacking and interfering with DNA, the genetic material in a cell. A liposome is a microscopic sphere with two layers of fat surrounding it. Giving drugs in this form minimizes adverse side effects and allows the drug to be more active.
How It Is Given:
Intravenously (by vein); the color of the solution is red.
Immediate Side Effects (beginning within 24 hours):
- Itching, hives, or a red rash can occur at the injection site and along the vein while the drug is being given. This subsides as soon as the injection of the drug is completed.
- Flushing, a feeling of tightness in the chest, chest or back pain, shortness of breath, fast heart rate, chills, a choking sensation, and a lowering of blood pressure can occur while the drug is being given.
Early Side Effects (beginning within the first week):
- Mild nausea may occur.
- Urine may be pink or red in color for as long as 48 hours after the treatment.
Late Side Effects (beginning after one week):
- A temporary decrease in blood cell counts (white blood cells and platelets) can occur within one to two weeks after treatment.
- Increased sensitivity, redness, and possible peeling of the skin on the hands and feet can occur.
- Temporary thinning or loss of hair can occur two to four weeks after treatment.
- Mouth sores can develop within one week after you have received the drug.
- Damage to the heart muscle can occur after a certain dose level is reached. Studies may be required to check heart function.
Special Points:
- Do not take aspirin, ibuprofen (e.g., Motrin®, Advil®), or products containing them unless your doctor prescribes them.
- Tell your doctor or nurse if you are taking any other medications, including over-the-counter preparations that do not require a prescription, herbal remedies, vitamins, or dietary supplements. Some of these may interfere with your chemotherapy.
- Perform mouth care as instructed by your doctor or nurse.
Call Your Doctor or Nurse If You:
- Have a fever of 100.5º F (38º C) or higher.
- Experience pain, redness, swelling, or blistering near the injection site.
- Develop mouth sores.
- Have black bowel movements, bruising, a faint red rash, or any other signs of bleeding.
- Have any unexpected or unexplained problems.
- Have any questions or concerns.
