Also Known As: Cytoxan®-Oral
Cyclophosphamide may stop cancer cells from growing by attacking and interfering with DNA, the genetic material in cells.
How It Is Given:
Orally (by mouth)
Early Side Effects (beginning within one week):
- Mild nausea or vomiting can occur within one week of starting cyclophosphamide and anytime during treatment.
- Bladder irritation in the form of burning on urination or blood in the urine can occur while taking the medication.
Late Side Effects (beginning after one week):
- A temporary decrease in blood cell counts (white blood cells and platelets) can occur one to two weeks after treatment.
- In women, menstrual periods can become irregular or stop and fertility may be decreased. In men, sperm production and fertility may be reduced. Please discuss these side effects with your doctor or nurse before beginning treatment.
- Temporary thinning or loss of hair is common and can occur two to three weeks after each treatment.
Special Points:
- Take this medicine in the morning or early afternoon. Avoid taking it at night.
- Drink at least two quarts of fluid a day while taking cyclophosphamide.
- Urinate every three to four hours and before bedtime while you are taking cyclophosphamide and for 24 hours after treatment.
- Do not take aspirin, ibuprofen (e.g., Motrin®, Advil®) or products containing them, unless your doctor prescribes them.
- Tell your doctor or nurse if you are taking any other medications, including over-the-counter preparations that do not require a prescription, herbal remedies, vitamins, or dietary supplements. Some of these may interfere with your chemotherapy.
Call Your Doctor or Nurse If You:
- Are unable to drink fluids.
- Have pain while you urinate or blood in your urine.
- Have a fever of 100.5° F (38° C) or higher.
- Have any questions or concerns.
- Have any unexpected, unexplained problems.
