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Also Known As: Leukeran®

Chlorambucil stops cancer cells from growing by attacking and interfering with DNA, the genetic material in cells.

How It Is Given:

Orally (by mouth)

Immediate Side Effect (beginning within 24 hours):

  • Mild nausea and vomiting may occur while the drug is being given.

Late Side Effect (beginning after one week):

  • A temporary decrease in blood cell counts--white blood cells and platelets--may occur while receiving the drug.

Special Points:

  • Take the medication with plenty of water.
  • Taking the medication after a meal may help decrease nausea.
  • Store the medication at room temperature away from sunlight, excessive heat, and moisture.
  • Do not take aspirin, ibuprofen (e.g., Motrin®, Advil®), or products containing them unless your doctor prescribes them.
  • Tell your doctor or nurse if you are taking any other medications, including over-the-counter preparations that do not require a prescription, herbal remedies, vitamins, or dietary supplements. Some of these may interfere with your chemotherapy.

Call Your Doctor or Nurse If You Have:

  • A fever of 100.5º F (38º C) or higher.
  • Black bowel movements, bruising, a faint red rash, or any other signs of bleeding.
  • Any unexplained or unexpected problems.
  • Any questions or concerns.
Last Updated: Mar. 27, 2003
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