The exact mechanism of how arsenic trioxide works is not well understood. It is used primarily in acute promyelocytic leukemia and is being investigated for use in other malignancies.
How It Is Given:
Intravenously (by vein, IV)
Side Effects:
- Low blood cell counts-white blood cells and platelets (may be severe and require stopping treatment)
- Irregularities in heart rhythm
- Swelling (common) and weight gain, rarely-may lead to difficulty breathing and respiratory failure
- Lightheadedness
- Fatigue
- Numbness and tingling in extremities (uncommon)
- Elevated blood sugar (mild)
- Nausea, vomiting, inability to eat, and abdominal pain (common and treatable)
- Mouth sores, swollen gums, and tongue discoloration
- Liver failure (can be life-threatening)
- Flu-like symptoms
- Flushing, skin dryness, itching, and rashes (common)
Special Points:
- Do not take this drug without telling your doctor if you have any of the following: heart disease, diabetes, or peripheral neuropathy.
- Do not take this drug if you are pregnant or breast feeding.
Call Your Doctor or Nurse If You Have:
- Bleeding, bruising, black tarry stools, blood in the urine or stools or a pinpoint red rash on the skin.
- Any unexpected or unexplained problems.
- Any questions or concerns.
