Also Known As: Vesanoid, Retin-A
Tretinoin works somewhat differently than other drugs for cancer chemotherapy. Whereas most drugs work by directly killing cancer cells, tretinoin causes the very immature cancer cells to mature (a process known as differentiation). The mature cells then undergo a natural death.
How It Is Given:
Orally (by mouth)
Immediate Side Effect (beginning within 24 hours):
- A headache may occur several hours after taking the drug. It usually disappears after several days. Acetaminophen (Tylenol®) or codeine may be needed to relieve the headache.
Early Side Effect (beginning within one week):
Late Side Effects (beginning after one week):
- Bone and joint pain (uncommon)
- Increased triglyceride levels in the blood
Special Points:
- Men and women on Tretinoin must use effective birth control during the time they are receiving the drug and for at least three months after stopping the drug.
- Tretinoin may cause damage to a fetus. If you think you may be pregnant, notify your physician immediately.
- Store Tretinoin at room temperature in original packaging out of direct sunlight.
- Take Tretinoin as directed.
- Be sure your doctor or nurse is aware of any other medications, including over-the-counter drugs, you may be taking while receiving this medication.
Call Your Doctor or Nurse If You:
- Have shortness of breath.
- Have a fever greater than 100.5° F (38° C).
- Have swelling of upper or lower extremities.
- Have a change in your breathing.
- Have bone pain that is not relieved by acetaminophen.
- Are unable to take Tretinoin.
- Have a persistent headache unrelieved by acetaminophen.
- Think you may be pregnant.
- Have any questions or concerns.
- Have any unexpected, unexplained problems.
