Also Known As: Folex®. Mexate®
Late Effect (1st of 3)
Osteonecrosis (destruction of bone)
Your risk is greater if:
- You also received corticosteroids, especially dexamethasone.
- You were treated between the ages of 9-18.
Recommended evaluation
Management
- You may need to consult with an orthopedic surgeon.
Late Effect (2nd of 3)
Possible affect on the intellect (e.g., lowered IQ [especially if you also received radiation therapy to the head], and learning disabilities such as decreased ability to process information, poor memory in some areas, short attention span, and difficulty with math, reading comprehension, and planning/organizational skills [especially in survivors of leukemia and lymphoma])
Your risk is greater if:
- You received high doses of the drug.
- You also had methotrexate that was given directly into the spinal canal (intrathecal administration).
- You also had radiation of more than 18 Gy to the head.
- You received treatment with dexamethasone.
Recommended Evaluation
- Regular assessment of educational or vocational progress, which may include neuropsychological (psychometric) testing
Management
- You may require special assistance in school including possible placement in special education classes.
Late Effect (3rd of 3)
Thinning of the bones (osteopenia or osteoporosis)
Your risk is greater if:
- You also received corticosteroids (prednisone, dexamethasone).
- You also had radiation to the head, neck, spine, ovaries or testicles, or total body irradiation that resulted in growth hormone deficiency, ovarian failure, or testicular failure.
Recommended evaluation
- Ask your doctor about the need for a bone mineral density study.
Management
- Take calcium supplements of 1,000-1,500 mg a day.
- Discuss hormone replacement therapy with your doctor if you also have ovarian or testicular failure.
