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Also Known As: Matulane®
Late Effect (1st of 2)
- Decreased functioning of the ovaries in females or testes in males (hypogonadism)
- Infertility
- Early menopause
Your risk is greater if:
- You are male.
- You are female and were treated during or after puberty.
- It was combined with
-Other alkylating agents
--Radiation to the testicles, pelvis, or total body
- You received a high dose of the drug.
Recommended Evaluation
- History and physical exam, especially sexual history in males and menstrual history in females yearly
- Hormone levels (females - FSH, LH, estradiol; males - LH, FSH, testosterone), and semen analysis as indicated based on need
Management
- Because of the risk of early menopause, females should carefully weigh a decision to delay childbearing.
- You may need a referral to an endocrinologist or a fertility specialist regarding fertility. Sometimes, recovery of fertility may occur spontaneously many years after treatment.
- Your doctor may recommend a bone mineral density to see if you have osteopenia or osteoporosis.
- You may benefit from hormone replacement therapy; discuss it with your doctor.
Late Effect (2nd of 2)
- Acute myeloid leukemia (AML)
- Myelodysplasia (pre-leukemia syndromes)
Your risk is greater if:
- You had a splenectomy (removal of the spleen).
- You received the drug once a week or more frequently.
- It has been less than five years since you had the drug. (These side effects are seen most commonly in the first five years after treatment.)
Recommended Evaluation
- Physical exam yearly
- Complete blood count and differential yearly
- Evaluation of symptoms of fatigue, pallor, petechiae (small red rash), and bone pain
- A bone marrow exam if you have any symptoms
Management
- You will be referred to a medical or pediatric oncologist if you are diagnosed with either condition.
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