3F8 is an antibody that attaches to neuroblastoma cells and helps focus a patient’s own immune system — especially white blood cells — to attack neuroblastoma. Granulocytes make up one kind of white blood cells. GM-CSF increases the number of granulocytes, and makes them better killers of cancer.
3F8 is an investigational drug that has been used in patients with neuroblastoma at Memorial Sloan Kettering for many years. This study will allow 3F8 to be given, in combination with GM-CSF, to patients with high-risk neuroblastoma. This includes patients who have no signs of cancer after other treatments but whose cancer has a chance of coming back (relapsing) and patients whose cancer is not responding to other kinds of treatment.