Medulloblastoma and primitive neuroectodermal tumors (PNET) of the central nervous system are challenging to treat. Therapy may consist of a combination of surgery, chemotherapy, and/or radiation therapy, but these tumors often return or persist despite treatment.
Some patients have done better than expected with the drugs temozolomide and irinotecan. In this Children’s Oncology Group study, researchers are evaluating temozolomide and irinotecan in patients with medulloblastoma or PNET whose tumors have returned or persisted despite therapy.
Some patients will also receive bevacizumab, a drug that works by inhibiting the growth of the blood vessels that tumors need to grow and spread. Investigators will also see how well patients fare when they receive temozolomide, irinotecan, and bevacizumab. Patients will be randomly assigned to receive the two-drug regimen or the three-drug regimen.