Diffuse pontine glioma is a type of brain stem cancer most often diagnosed in children. It is very challenging to treat successfully. Doctors are therefore seeking more effective therapies.
Radiation therapy is a common part of brain tumor treatment. Temozolomide is used to treat adult brain cancers. In this study, researchers want to find the highest dose of an investigational drug called veliparib (ABT-888) that can be given safely with radiation therapy and then with temozolomide in children who are newly diagnosed with diffuse pontine glioma.
Veliparib kills cancer cells by blocking a protein called PARP, thereby preventing the repair of DNA or genetic damage in cancer cells caused by treatment and possibly making them more susceptible to anticancer therapies, such as temozolomide and radiation. Veliparib and temozolomide are both taken orally (by mouth).
This study is being conducted by the Pediatric Brain Tumor Consortium, a collaboration among U.S. centers dedicated to improving the care of children with brain tumors.