I am a pediatric neuro-oncologist who is a specialist in brain tumor biology, and I take care of children with brain tumors. I am an authority on the mechanisms by which cancer metastasizes throughout the body, particularly through the establishment of blood vessels that tumors need to grow and spread.
I have a joint appointment with Weill Cornell Medical College as the Stavros S. Niarchos Chair, where I run a laboratory studying the biology of medulloblastoma and high-grade gliomas. We are working to understand how cells in the environment around a tumor foster tumor growth. For example, we have found that brain tumors may send out signals to make certain nascent cells in the bone marrow multiply and travel to the brain to induce the formation of new blood vessels to feed brain tumors. We're trying to develop monoclonal antibodies to receptors on these bone marrow cells so we can learn how to target them with therapy and inhibit them.