Biparental HLA Haplotype Disparate T-cell Depleted Transplants for Patients Lacking an HLA-Compatible Donor

Protocol
12-053
Full Title
Biparental HLA Haplotype Disparate T-cell Depleted Transplants for Patients Lacking an HLA-Compatible Donor
Phase
II
Purpose

In some patients who need a blood stem cell transplant, a well-matched H (human) L (leukocyte) A (antigen)-compatible donor cannot be found in a timely fashion. HLA antigens are proteins expressed on the surface of all cells other than red blood cells. Transplant outcome is generally much better when the patient and donor are well HLA-matched. Doctors in this study are trying to develop ways to make transplants from HLA-partially matched donors as safe and effective as transplants from HLA-matched donors.

Patients with different diseases (for example, leukemia, lymphoma, myelodysplastic syndrome, bone marrow failure, or immunodeficiency diseases) who need a hematopoietic blood stem cell transplant but who don’t have an HLA-matched donor are eligible. In this study, the patient will receive blood stem cells from two different related donors, each of whom shares one-half of the patient’s HLA type. T cells from the donor graft are removed to try and prevent an inflammatory reaction in the patient called graft-versus-host disease (GvHD). GvHD is caused by T cells in the graft which recognize the patient¿s cells as different.

Doctors hope that this approach can be used without increasing the risk of side effects, that it can improve a patient’s recovery after transplantation, and that it increases the effect that a donor’s immune cells may have in helping to rid the patient’s body of any lingering cancer cells.

Eligibility

To be eligible for this study, patients must meet several criteria, including but not limited to the following:

For more information about this study and to inquire about eligibility, please contact Dr. Richard O’Reilly at 212-639-5957, Dr. Trudy Small at 212-639-5965, Dr. Farid Boulad at 212-639-6684, or Dr. Nancy A. Kernan at 212-639-7250.
Disease(s)
Blood & Marrow Stem Cell Transplantation
Hematology: Hematologic Disorders
Hematology: Myelodysplastic Syndrome
Leukemia: Acute Myelocytic Leukemia
Leukemia: Chronic Myelocytic Leukemia
Leukemia: Myelodysplastic Syndrome
Lymphoma: Non-Hodgkin's Lymphoma
Locations