Cyclophosphamide and topotecan are standard anticancer drugs used to treat patients with Ewing’s sarcoma and neuroblastoma. Despite this therapy, however, in some patients the cancer returns or persists. In this study, researchers are evaluating the safety and effectiveness of adding the drug bevacizumab to cyclophosphamide and topotecan therapy in children and adolescents with Ewing’s sarcoma or neuroblastoma that has returned or persists despite standard therapy.
Bevacizumab works by inhibiting the formation of blood vessels that tumors need to grow and spread. It is given intravenously (by vein). It is already approved for the treatment of several other types of cancer, but its use in this study is considered investigational.
This study is coordinated by POETIC, a consortium of several U.S. hospitals that conducts clinical trials for children with cancer.