Irinotecan and temozolomide are drugs routinely used to treat patients with Ewing sarcoma whose cancer has returned. Patients with newly diagnosed Ewing sarcoma usually receive a standard regimen of five chemotherapy drugs in combination with surgery and/or radiation therapy. Yet the cancer sometimes returns despite this approach.
In this study, researchers want to determine if giving irinotecan and temozolomide along with the initial five-drug chemotherapy regimen reduces the risk of the cancer returning in infants, children, adolescents, and young adults newly diagnosed with Ewing sarcoma. This study will evaluate the safety and effectiveness of this treatment.