Mutations of the ALK gene may fuel cancer growth. LDK378 is an investigational drug that may inhibit the growth of tumors containing an ALK mutation.
In this study, researchers want to find the highest dose of LDK378 that can be given safely in children with tumors that contain ALK mutations. Most patients in this study will have neuroblastoma, anaplastic large cell lymphoma, inflammatory myofibroblastoma, or rhabdomyosarcoma. LDK378 is a capsule that is taken orally (by mouth).