Protocol
08-129
Full Title
Carcinogen Metabolism, DNA Repair, Parental Exposures and Retinoblastoma (COG AEPI05N1)
Purpose
Retinoblastoma (RB) is a tumor that is found in the retina (the back layer) of the eye. It can occur either in one or both eyes. The purpose of this Children’s Oncology Group study is to determine how genes and certain factors of day-to-day life (exposures) affect a person’s chances of developing RB. Researchers will compare the exposures and genes of children with RB (who have no family history of RB) with those of children who do not have RB.
Children participating in this study will provide a blood, saliva, or tumor tissue sample that will be evaluated for genetic mutations. Participating parents will also undergo genetic testing and will be asked questions about their job history, exposures to medical radiation, diet, tobacco and alcohol use, use of pesticides, and any fertility treatments. The genetic testing offered in this study will be provided free of charge to participants.
Investigator
Dunkel, Ira, MD
Eligibility
To be eligible for this study, patients must meet several criteria, including but not limited to the following:
- Participating children with RB must have no family history of the disease and must have been diagnosed after July 1, 2006.
- Patients must live in the U.S. or Canada, have a telephone in the home, and have parents who speak English or Spanish.
- Control children (those without RB) must not be related to the patient.
For more information and to inquire about eligibility for this study, please contact Dr. Ira Dunkel at 212-639-2153.
Disease(s)
Retinoblastoma
