Early Onset and Familial Gastric Cancer Registry

Protocol
05-118
Full Title
Early Onset and Familial Gastric Cancer Registry
Purpose

While less common in the United States, worldwide there are approximately 1 million new cases of gastric cancer each year, making this disease one of the most common cancers. Memorial Sloan-Kettering Cancer Center has established the Early Onset and Familial Gastric Cancer Registry (EOFGC), with the primary objective of identifying factors that raise the risk of gastric cancer — especially inherited or acquired genetic alterations which cause gastric cancer in young patients.

The Registry prospectively collects epidemiological data, answers to a questionnaire about risk factors, family pedigrees, and biological material (including germline DNA) from patients with gastric cancer and matched “control” patients without the disease. Tumor tissue samples are also obtained from gastric cancer patients. From this clinical and epidemiological information and the accompanying biological material, researchers aim to identify the factors causing gastric cancer among individuals at high risk for this disease (especially due to inherited genetic alterations). The ultimate goal is to establish effective prevention and early detection strategies for those at high risk, and to develop new therapies for patients with more advanced disease.

MSKCC is the coordinating center for this study, along with four collaborating sites: The University of Southern California, NewYork-Presbyterian/Weill Cornell Medical Center, Queens Medical Center, and Obafemi Univeristy Hospital (Nigeria). At the collaborating institutions, data — including family pedigrees and blood specimens for germline DNA — are collected and sent to MSKCC for analysis.

Eligibility

To be eligible for this study, participants must meet the following criteria:

  • Patients: Any individual diagnosed with gastric or gastroesophageal junction cancer or any individual with a personal or family history of a genetic mutation known to cause gastric cancer.
  • Controls: Any individual who does not have gastric or gastroesophageal cancer and is not blood related to a patient or relative participant. These participants cannot have a family history of a genetic mutation known to cause gastric cancer.
  • All participants must be age 18 or older.

For more information and to see if you are eligible for this study, please contact the Registry Team at GastricCancerRegistry@mskcc.org.

Disease(s)
Hereditary Cancer & Genetics
Upper Gastrointestinal: Gastric Cancer