Stem cell transplantation is a treatment for leukemia or myelodysplastic syndrome (MDS). However, in some patients, leukemia or MDS cells remain in the body or come back after disappearing, despite the stem cell transplant.
In this study, researchers have taken a protein called the Wilms’ Tumor Protein (WT1) — which can be found in some, but not all, leukemic cells — and, in the laboratory, they have grown immune cells (T cells, a type of white cell) which are sensitized to that protein.
The purpose of this study is to found out if, in patients with leukemia that has the WT1 protein, the administration of “WT1-sensitized T cells” grown from an HLA-matched donor can be performed safely. Researchers want to learn whether the WT1-sensitized T cells can attack the protein and kill the leukemia or MDS cells. They also hope to learn what the WT1-sensitized T cells do to each patient’s disease.