Cytomegalovirus (CMV) is a potential complication after stem cell transplantation. There are drugs used to treat CMV, but in some patients the virus has become resistant to these drugs, or the patient cannot tolerate them. In these cases, giving infusions of T cells (white blood cells) that are immune to CMV may be a potentially effective treatment.
In this study, researchers are evaluating the effectiveness of giving CMV-immune T cells to patients with persistent CMV infection after stem cell transplantation. The T cells are donated either by the patient’s stem cell donor, or — in the case of patients whose donors don’t have CMV-immune stem cells — they are donated by a “third party” whose T cells are immune to CMV. The T cells contributed by the donor are grown and “taught” in the laboratory how to attack CMV.