Brain tumors in children are often challenging to treat successfully. The purpose of this Pediatric Brain Tumor Consortium study is to find the highest dose of an investigational drug called p28 (NSC745104) that can be given safely in children whose brain tumors have come back or continued to grow despite treatment.
Many cancer cells have a protein called p53 that does not work properly. This protein normally puts the breaks on rampant cell growth, and when it does not function well, cells can continue to grow uncontrollably (as cancer cells do). The p28 drug is designed to find and kill cancer cells with dysfunctional p53. It is given intravenously (by vein).