Memorial Sloan-Kettering ranked number 11 among the top 50 pediatriccancer hospitals in U.S. News & World Report’s annual Best Children’s Hospitals issue. The New York Daily News reported on the rankings.
Epidemiologist and physicianPeter Bach authored an essay opining that many doctors will ignore current recommendations to screen for cancer less often and continue to practice as they have been.
Epidemiologist and physician Peter Bach explored the growing concern about overtesting and overtreating patients due to increased recognition of risks and side effects.
Medical oncologist Yelena Janjigian was interviewed about her patient, Red Hook movie producer Angelica Strong, who is organizing fundraisers to raise awareness and funds for stomach cancer.
Plastic surgeonAndrea Pusic discussed some women’s initial aversion to breast reconstruction at the beginning of treatment. Only about a third of women undergo immediate breast reconstruction after mastectomy, according to a 2011 analysis in the Annals of Surgical Oncology, with 11.5 percent delaying reconstructive surgery for months or years, and more than half of patients foregoing it altogether.
A study led by molecular epidemiologist Helena Furberg reported the discovery of a gene that predicts smoking behavior. Dr. Furberg noted that the next research step would be to see if currently available smoking cessation medications would work differently in people who carry these genes.
Survivorship Initiative Director Mary McCabe commented on the importance of cancer survivorship programs. She said these programs ensure that cancer survivors receive proper follow-up care and teach survivors how to communicate their needs to their healthcare team.
Medical oncologist Robert Motzer discussed encouraging findings from a phase III study he led comparing the safety and efficacy of two kidney cancer drugs. Dr. Motzer’s team found that patients taking the investigational drug tivozanib were half as likely to need a break from the medication due to side effects as patients taking sorafenib (Nexavar®).
Michel Sadelain, Center for Cell Engineering Director, discussed the burgeoning field of adoptive cell transfer (ACT) as a treatment for cancer. Dr. Sadelain, who is involved in several ACT trials at Memorial Sloan-Kettering, notes that interest in these types of cell-based therapies is growing, but serious hurdles must be overcome if any form of ACT is to become widely available.
Surgery Department Chair Peter Scardino spoke about biomarkers developed at Memorial Sloan-Kettering that, when used together with PSA tests, can reduce the need for prostate biopsies by more than 50 percent.
Memorial Sloan-Kettering patient Seun Adebiyi launched Nigeria’s national bone marrow registry after experiencing firsthand the difficulty of finding donors for patients of African descent.
Dermatologist Kishwer Nehal was interviewed about research from Missouri University of Science and Technology that looked at what happens to cells containing zinc oxide when exposed to sunlight.
Gynecologic oncologist Douglas Levine spoke about risk-reducing surgery for carriers of BRCA gene mutations. BRCA gene mutations, which are much more prevalent in Jewish people of Ashkenazi descent than in the general population, increase the likelihood of developing ovarian or breast cancer.
A process in which anything complex is separated into simple or less complex parts.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
bone marrow (bone MAYR-oh)
The soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
breast (brest)
Glandular organ located on the chest. The breast is made up of connective tissue, fat, and breast tissue that contains the glands that can make milk. Also called mammary gland.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
breast cancer (brest KAN-ser)
Cancer that forms in tissues of the breast, usually the ducts (tubes that carry milk to the nipple) and lobules (glands that make milk). It occurs in both men and women, although male breast cancer is rare.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
breast reconstruction (brest REE-kun-STRUK-shun)
Surgery to rebuild the shape of the breast after a mastectomy.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
cancer (KAN-ser)
A term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body through the blood and lymph systems. There are several main types of cancer. Carcinoma is a cancer that begins in the skin or in tissues that line or cover internal organs. Sarcoma is a cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Leukemia is a cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of abnormal blood cells to be produced and enter the blood. Lymphoma and multiple myeloma are cancers that begin in the cells of the immune system. Central nervous system cancers are cancers that begin in the tissues of the brain and spinal cord. Also called malignancy.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
cell (sel)
The individual unit that makes up the tissues of the body. All living things are made up of one or more cells.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
chemotherapy (KEE-moh-THAYR-uh-pee)
Treatment with drugs that kill cancer cells.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
clinical (KLIH-nih-kul)
Having to do with the examination and treatment of patients.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
dermatologist (der-muh-TAH-loh-jist)
A doctor who has special training to diagnose and treat skin problems.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
drug (drug)
Any substance, other than food, that is used to prevent, diagnose, treat or relieve symptoms of a disease or abnormal condition. Also refers to a substance that alters mood or body function, or that can be habit-forming or addictive, especially a narcotic.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
efficacy (EH-fih-kuh-see)
Effectiveness. In medicine, the ability of an intervention (for example, a drug or surgery) to produce the desired beneficial effect.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
Ensure (en-SHER)
A nutritional drink that may help people who cannot get everything they need in their diet from foods and other drinks. It may be taken by mouth or given through a small tube inserted through the nose into the stomach or the small intestine. It may also be given through a small tube that is put into the stomach or intestinal tract through an opening made on the outside of the abdomen. Ensure is a type of dietary supplement. Also called polymeric enteral nutrition formula.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
epidemiologist (EH-pih-DEE-mee-AH-loh-jist)
A scientist who studies the patterns, causes, and control of disease in groups of people.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
estrogen (ES-truh-jin)
A type of hormone made by the body that helps develop and maintain female sex characteristics and the growth of long bones. Estrogens can also be made in the laboratory. They may be used as a type of birth control and to treat symptoms of menopause, menstrual disorders, osteoporosis, and other conditions.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
experimental (ek-SPAYR-ih-men-tul)
In clinical trials, refers to a drug (including a new drug, dose, combination, or route of administration) or procedure that has undergone basic laboratory testing and received approval from the U.S. Food and Drug Administration (FDA) to be tested in human subjects. A drug or procedure may be approved by the FDA for use in one disease or condition, but be considered experimental in other diseases or conditions. Also called investigational.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
FDA
An agency in the U.S. federal government whose mission is to protect public health by making sure that food, cosmetics, and nutritional supplements are safe to use and truthfully labeled. The FDA also makes sure that drugs, medical devices, and equipment are safe and effective, and that blood for transfusions and transplant tissue are safe. Also called Food and Drug Administration.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
follow-up (FAH-loh-up)
Monitoring a person's health over time after treatment. This includes keeping track of the health of people who participate in a clinical study or clinical trial for a period of time, both during the study and after the study ends.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
gene (jeen)
The functional and physical unit of heredity passed from parent to offspring. Genes are pieces of DNA, and most genes contain the information for making a specific protein.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
gynecologic (GY-neh-kuh-LAH-jik)
Having to do with the female reproductive tract (including the cervix, endometrium, fallopian tubes, ovaries, uterus, and vagina).
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
immune system (ih-MYOON SIS-tem)
The complex group of organs and cells that defends the body against infections and other diseases.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
immunotherapy (IH-myoo-noh-THAYR-uh-pee)
Treatment to boost or restore the ability of the immune system to fight cancer, infections, and other diseases. Also used to lessen certain side effects that may be caused by some cancer treatments. Agents used in immunotherapy include monoclonal antibodies, growth factors, and vaccines. These agents may also have a direct antitumor effect. Also called biological response modifier therapy, biological therapy, biotherapy, and BRM therapy.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
investigational (in-VES-tih-GAY-shuh-nul)
In clinical trials, refers to a drug (including a new drug, dose, combination, or route of administration) or procedure that has undergone basic laboratory testing and received approval from the U.S. Food and Drug Administration (FDA) to be tested in human subjects. A drug or procedure may be approved by the FDA for use in one disease or condition, but be considered investigational in other diseases or conditions. Also called experimental.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
ipilimumab (ih-pih-LIH-myoo-mab)
A drug used to treat melanoma that has spread to other parts of the body or that cannot be removed by surgery. It is also being studied in the treatment of other types of cancer. Ipilimumab binds to a substance called CTLA-4, which is found on the surface of T cells (a type of white blood cell). Ipilimumab may block CTLA-4 and help the immune system kill cancer cells. It is a type of monoclonal antibody. Also called MDX-010 and Yervoy.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
mastectomy (ma-STEK-toh-mee)
Surgery to remove the breast (or as much of the breast tissue as possible).
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
mean (meen)
A statistics term. The average value in a set of measurements. The mean is the sum of a set of numbers divided by how many numbers are in the set.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
medical oncologist (MEH-dih-kul on-KAH-loh-jist)
A doctor who specializes in diagnosing and treating cancer using chemotherapy, hormonal therapy, biological therapy, and targeted therapy. A medical oncologist often is the main health care provider for someone who has cancer. A medical oncologist also gives supportive care and may coordinate treatment given by other specialists.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
medication (MEH-dih-KAY-shun)
A legal drug that is used to prevent, treat, or relieve symptoms of a disease or abnormal condition.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
medicine (MEH-dih-sin)
Refers to the practices and procedures used for the prevention, treatment, or relief of symptoms of a diseases or abnormal conditions. This term may also refer to a legal drug used for the same purpose.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
obesity (oh-BEE-sih-tee)
A condition marked by an abnormally high, unhealthy amount of body fat.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
oncologist (on-KAH-loh-jist)
A doctor who specializes in treating cancer. Some oncologists specialize in a particular type of cancer treatment. For example, a radiation oncologist specializes in treating cancer with radiation.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
oncology (on-KAH-loh-jee)
The study of cancer.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
ovarian (oh-VAYR-ee-un)
Having to do with the ovaries, the female reproductive glands in which the ova (eggs) are formed. The ovaries are located in the pelvis, one on each side of the uterus.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
oxide (OK-side)
A type of chemical substance that is a combination of oxygen and another substance. Oxides are found in essential oils.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
pediatric (pee-dee-A-trik)
Having to do with children.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
physician (fih-ZIH-shun)
Medical doctor.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
plastic surgeon (PLAS-tik SER-jun)
A surgeon who specializes in reducing scarring or disfigurement that may occur as a result of accidents, birth defects, or treatment for diseases.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
postmenopausal (post-MEH-nuh-PAW-zul)
Having to do with the time after menopause. Menopause (“change of life”) is the time in a woman's life when menstrual periods stop permanently.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
progression (pruh-GREH-shun)
In medicine, the course of a disease, such as cancer, as it becomes worse or spreads in the body.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
prostate (PROS-tayt)
A gland in the male reproductive system. The prostate surrounds the part of the urethra (the tube that empties the bladder) just below the bladder, and produces a fluid that forms part of the semen.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
PSA
A protein made by the prostate gland and found in the blood. PSA blood levels may be higher than normal in men who have prostate cancer, benign prostatic hyperplasia (BPH), or infection or inflammation of the prostate gland. Also called prostate-specific antigen.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
radiation (RAY-dee-AY-shun)
Energy released in the form of particle or electromagnetic waves. Common sources of radiation include radon gas, cosmic rays from outer space, medical x-rays, and energy given off by a radioisotope (unstable form of a chemical element that releases radiation as it breaks down and becomes more stable).
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
reconstructive surgery (REE-kun-STRUK-tiv SER-juh-ree)
Surgery that is done to reshape or rebuild (reconstruct) a part of the body changed by previous surgery.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
screening (SKREE-ning)
Checking for disease when there are no symptoms. Since screening may find diseases at an early stage, there may be a better chance of curing the disease. Examples of cancer screening tests are the mammogram (breast), colonoscopy (colon), and the Pap test and HPV test (cervix). Screening can also include checking for a person’s risk of developing an inherited disease by doing a genetic test.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
sorafenib (sor-A-feh-nib)
A drug used to treat advanced kidney cancer and a type of liver cancer that cannot be removed by surgery. It is also being studied in the treatment of other types of cancer. Sorafenib stops cells from dividing and may prevent the growth of new blood vessels that tumors need to grow. It is a type of kinase inhibitor and a type of antiangiogenesis agent. Also called BAY 43-9006, Nexavar, and sorafenib tosylate.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
sunscreen (SUN-skreen)
A substance that helps protect the skin from the sun's harmful rays. Sunscreens reflect, absorb, and scatter both ultraviolet A and B radiation to provide protection against both types of radiation. Using lotions, creams, or gels that contain sunscreens can help protect the skin from premature aging and damage that may lead to skin cancer.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
surgery (SER-juh-ree)
A procedure to remove or repair a part of the body or to find out whether disease is present. An operation.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
survivorship (ser-VY-ver-ship)
In cancer, survivorship covers the physical, psychosocial, and economic issues of cancer, from diagnosis until the end of life. It focuses on the health and life of a person with cancer beyond the diagnosis and treatment phases. Survivorship includes issues related to the ability to get health care and follow-up treatment, late effects of treatment, second cancers, and quality of life. Family members, friends, and caregivers are also part of the survivorship experience.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
thoracic (thor-A-sik)
Having to do with the chest.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
tissue (TIH-shoo)
A group or layer of cells that work together to perform a specific function.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)
will (wil)
A legal document in which a person states what is to be done with his or her property after death, who is to carry out the terms of the will, and who is to care for any minor children.
Source: The National Cancer Institute's Dictionary of Cancer Terms (http://www.cancer.gov/dictionary)