I am a board-certified surgeon with clinical expertise diagnosing and treating breast cancer. In addition to my clinical practice, I am active in translational research and am the principal investigator of the William F. Keck Laboratory for Breast Cancer Research at Memorial Sloan-Kettering.
The overriding goal of my laboratory research has been to develop a better understanding of the molecular genetics of breast cancer with a focus on the progression of high risk lesions such as lobular carcinoma in situ (LCIS). Previous data suggests that LCIS is a risk marker and does not become invasive cancer; however recent studies have reopened this debate. We hypothesize that molecular changes present in LCIS can be used to predict a woman's risk of developing invasive breast cancer. We are testing this hypothesis using a variety of gene expression assays with the support of Memorial Sloan-Kettering’s genomics core facility. This project is supported by the Geoffrey Beene Cancer Research Center and Susan G. Komen for the Cure.
In collaboration with Dr. Neal Rosen, members of my laboratory and I are also investigating the signaling pathways involved when ductal carcinoma in situ (DCIS) progresses to become invasive ductal cancer. We are focusing on the role of specific targets (including Her2-neu) in the Her2/PI3K pathway.
My clinical research focuses on the role of surgery in Stage IV breast cancer. I am the principal investigator of a multi-institutional study sponsored by the Translational Breast Cancer Research Consortium (TBCRC) designed to collect information regarding the use of surgery for the primary breast tumor in patients with metastatic disease.
Appointments for New Patients
646-497-9064
Phone
646-888-5432
Education
MD, University of Colorado Health Sciences Center
Residencies
Ochsner Medical Institutions (New Orleans)
Fellowships
Memorial Sloan-Kettering Cancer Center
