I am a neurosurgeon and laboratory investigator who specializes in the treatment of patients with primary brain tumors and metastatic brain tumors, with career experience in the computational analysis and molecular profiling of human and mouse tumors for translational research. I am a member of the Brain Tumor Center and the Human Oncology and Pathogenesis Program. In the laboratory, my research focuses on the genomic analysis of human and mouse gliomas and medulloblastomas.
I have identified several new gene fusions affecting receptor tyrosine kinases in glioma and recently have used combined genomics and proteomics to characterize molecular subclasses of glioblastoma that feature distinct patterns of activation among signaling pathways. As a funded co-investigator and external co-chair in The Cancer Genome Atlas pilot project, I developed microarray and computational methods to identify candidate translocations and gene fusions from microarray data.