Paclitaxel and trastuzumab are anticancer drugs used to treat breast cancer. Trastuzumab is used to treat women whose breast cancers are fueled by the HER2 protein. Despite these drugs, however, the breast cancer may continue to grow in some women.
In this study, researchers want to determine the highest dose of the investigational drug ganetespib which can be given in combination with paclitaxel and trastuzumab in women with HER2-positive metastatic breast cancer that is not responding to standard therapy. Ganetespib works by blocking heat-shock protein 90 (Hsp90), which may be more active in cancer cells and which partners with other proteins to send messages telling cancer cells to grow.
All three drugs used in this study are given intravenously.