I conduct clinical research investigating new ways to use cord blood to treat diseases of the blood and bone marrow. One approach is to increase the number of cord blood cells by combining two units from different donors (known as double-unit transplants). Another is transplanting umbilical cord blood after reduced intensity or non-myeloablative preparative regimens. These strategies promise to extend potentially curative therapy to many patients; and, encouragingly, patient survival after cord blood transplantation at Memorial Sloan-Kettering Cancer Center has been very promising, with preliminary results suggesting it is comparable to that of transplants from unrelated donors.
In addition, in collaboration with my scientific colleagues, I am conducting correlative laboratory studies to better understand the biology of cord blood transplantation. These studies should ultimately lead to improved treatment for patients with blood diseases.