Center of Comparative Medicine & Pathology: Publications

Original Articles

Altholtz LY,La Perle KM, Quimby FW. Dose-dependent hypothyroidism in mice induced by commercial trimethoprim-sulfamethoxazole rodent feed. Comp Med. 2006;56(5):395-401.

Au TJ, Carson J, Monette S, Finley DJ. Spray Cryotherapy is Effective for Bronchoscopic, Endoscopic, and Open Ablation of Thoracic Tissues. Interact Cardiovasc Thorac Surg. 2012; 15(4):580-584. 

Au JT, Mittra A, Wong J, Carpenter S, Carson J, Haddad D, Monette S, Ezell P, et al. Flexible CO2 laser and submucosal gel injection for safe endoluminal resection in the intestines. Surg Endosc. 2012;26(1):47-52.

Au JT, Wong J, Mittra A, Carpenter S, Haddad D, Carson J, Jayaraman S, Monette S, Solomon SB, Ezell P, et al. Irreversible electroporation is a surgical ablation technique that enhances gene transfer. Surgery. 2011; 150(3):474-479.

Brentjens RJ, Santos E, Nikhamin Y, Yeh R, Matsushita M, La Perle K, et al. Genetically targeted T cells eradicate systemic acute lymphoblastic leukemia xenografts. Clin Cancer Res. 2007;13(18 Pt 1):5426-5435.

Burr HN, Lipman NS, White JR, Zheng J, Wolf FR. Strategies to Prevent, Treat, and Provoke Corynebacterium-Associated Hyperkeratosis in Athymic Nude Mice. JAALAS. 2011;50(3):378-388.

Burr HN, Wolf FR, Lipman NS. Corynebacterium bovis: epizootiologic features and environmental contamination in an enzootically infected rodent room. JAALAS. 2012;51(2):189-198.

Cassano AE, White JR, Penraat K, Wilson CD, Rasmussen S, Karatsoreos IN. Anatomic, hematologic, and biochemical features of C57BL/6NCrl mice maintained on chronic oral corticosterone. Comp Med. 2012; 62(5):348-360.

Clegg NJ, Couto SS, Wongvipat J, et al. MYC cooperates with AKT in prostate tumorigenesis and alters sensitivity to mTOR inhibitors. PLoS One. 2011;6(3):e17449. 

Cohen JK, Cai LQ, Zhu YS, La Perle KM. Pancreaticoduodenal arterial rupture and hemoabdomen in ACI/SegHsd rats with polyarteritis nodosa. Comp Med. 2007;57(4):370-376.

Collymore C, White JR, Lieggi C. Case Report: Trichodina xenopodus, a Ciliated Protozoan, in a Laboratory-Maintained Xenopus laevis. Comp Med. In press.

Corse E, Gottschalk RA, Park JS, Sepulveda MA, Loke P, Sullivan TJ, Johnson LK, et al. Cutting edge: chronic inflammatory liver disease in mice expressing a CD28-specific ligand. J Immunol. 2013;190(2):526-530.

Couto SS, Cao M, Duarte PC, et al. Simultaneous haploinsufficiency of Pten and Trp53 tumor suppressor genes accelerates tumorigenesis in a mouse model of prostate cancer. Differentiation. 2009;77(1):103-111.

Couto SS, Cardiff RD. The genomic revolution and endocrine pathology. Endocr Pathol. 2008;19(3):139-147.

Deodhar A, Monette S, Single G, et al. Renal Tissue Ablation with Irreversible Electroporation: Preliminary Results in a Porcine Model. Urology. 2011;77(3):754-760.

Deodhar A, Monette S, Single G, et al. Percutaneous Irreversible Electroporation Lung Ablation: Preliminary Results in a Porcine Model. Cardiovasc Intervent Radiol. 2011;34(6):1278-1287.

Donkor MK, Sarkar A, Savage PA, Franklin RA, Johnson LK, et al. T cell surveillance of oncogene-induced prostate cancer is impeded by T cell-derived TGF-β1 cytokine. Immunity. 2011;35(1):123-134.

Gaither AM, Baker KC, Gilbert MH, Blanchard JL, Liu DX, Luchins KR,  Bohm RP. Videotaped Behavior as a Predictor of Clinical Outcome in Rhesus Macaques (Macaca mulatta). Comp Med. 2014;64(3):193-9.

Glomski K,  Monette S, Manova K, et al. Deletion of Adam10 in Endothelial Cells Leads to Defects in Organ-specific Vascular Structures. Blood. 2011;118(4):1163-1174. 

Gravaghi C, La Perle KM, Ogrodwski P, et al. Cox-2 expression, PGE(2) and cytokines production are inhibited by endogenously synthesized n-3 PUFAs in inflamed colon of fat-1 mice.  J Nutr Biochem. 2011;22(4):360-365. 

Hartrampf S, Dudakov JA, Johnson LK, et al. The central nervous system is a target of acute graft versus host disease in mice. Blood. 2013;Jan 8[Epub ahead of print].

Hockemeyer D, Palm W, Wang RC, Couto SS, et al. Engineered telomere degradation models dyskeratosis congenita. Genes Dev. 2008;22(13):1773-1785.

Issuree PD, Maretzky T, McIlwain DR, Monette S, et al. iRHOM2 is a critical pathogenic mediator of  inflammatory arthritis. J Clin Invest. 2013;Jan 25[Epub ahead of print].

King JC, Xu J, Wongvipat J, Hieronymus H, Carver BS, Leung DH, Taylor BS, Sander C, Cardiff RD, Couto SS, et al. Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis.  Nat Genet. 2009;41(5):524-526.

Lipman NS, Homberger FR. Rodent Quality Assurance Testing: Utilization of Sentinel Animal Systems.  Lab Anim. 2003;32(5):36-43.

Lipman NS, Jackson, LR, Trudel, LJ, and Weis-Garcia F.  Monoclonal versus polyclonal antibodies: Distinguishing characteristics, applications and information resources.  ILAR Journal. 2005;46(3):258-268.

Lipman NS, Perkins SE, Nguyen HT, Pfeffer M, and Meyer H. Mousepox resulting from use of ectromelia virus-contaminated, imported mouse serum. Comp Med. 2000; 50(4):426-435.

Liu X, He Y, Xiao K, White J, Fusco D, Papanicolaou G. Effect of linezolid on clinical severity and pulmonary cytokines in a murine model of influenza A and Staphylococcus aureus co-infection. PLoS ONE. In press. 

Mark WH, Romanienko P, Lipman NS, Lacy E. The new transgenic mouse core: No longer a facility just for making mice. Lab Anim. 2006;35(1):27-35.

McIntyre AR, Drummond RA, Riedel ER, Lipman NS. Automated mouse euthanasia in an individually ventilated caging system:  System development and assessment. JAALAS. 2007;46(2):65-73.

McIntyre A, La Perle KM. Hermaphroditism in 3 chimeric mice. Vet Pathol. 2007;44(2):249-252.

McIntyre AR, Lipman NS. Amoxicillin-Clavulanic Acid and trimethoprim–sulfamethoxazole in rodent Feed and Water: Effects of compounding on antibiotic stability. JAALAS. 2007;46(5):31-37.

Milsom JW, Trencheva K, Ezell P, Maggiori L, Pavoor R, Vitellaro M, Zhuo C, Makino T, Lee SW, Shukla PJ. Feasibility and Safety of Laparoscopic Colon Surgery Performed Under Intravenous Sedation and Local Anesthesia Using Microinvasive (<3 mm) Instruments: An Acute and Survival Study on Porcine Model. Surg Innov. 2014 Jun 5.

Milsom J, Trencheva K, Monette S, et al. Evaluation of the Safety, Efficacy, and Versatility of a New Surgical Energy Device (THUNDERBEAT) in Comparison with Harmonic ACE, LigaSure V, and EnSeal Devices in a Porcine Model. J Laparoendosc Adv Surg Tech A. 2012;22(4):378-86.

Mutlu AD, Cavallin LE, Vincent L, Chiozzini C, Eroles P, Duran EM, Asgari Z, Hooper AT, La Perle KM, et al. In vivo-restricted and reversible malignancy induced by human herpesvirus-8 KSHV: a cell and animal model of virally induced Kaposi's sarcoma. Cancer Cell. 2007;11(3):245-258.

Nathan C, Calingasan N, Nezezon J, Ding A, Lucia MS, La Perle K, et al. Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase.  J Exp Med. 2005;202(9):1163-1169.

Orange DE, Blachere NE, Fak J, Parveen S, Frank MO, Herre M, Tian S, Monette S, et al. Dendritic cells loaded with FK506 kill T cells in an antigen-specific manner and prevent autoimmunity in vivo. eLife. 2013;2:e00105. 

Parisi MA, Lipman NS, Clarke, CM, and Kapur R. Evaluation of Hox11L1 in the fmc/fmc rat model of chronic intestinal pseudo-obstruction. J Pediatr Surg. 2005;40(11):1760-1765.

Postel EH, Wohlman I, Zou X, Juan T, Sun N, D'Agostin D, Cuellar M, Choi T, Notterman DA, La Perle KM. Targeted deletion of Nm23/nucleoside diphosphate kinase A and B reveals their requirement for definitive erythropoiesis in the mouse embryo. Dev Dyn. 2009;238(3):775-787. 

Postel EH, Zou X, Notterman DA, La Perle KM. Double knockout Nme1/Nme2 mouse model suggests a critical role for NDP kinases in erythroid development. Mol Cell Biochem. 2009;329(1-2):45-50. 

Rasmussen S, Glickman G, Norinsky R, Quimby FW, Tolwani RJ. Construction noise decreases reproductive efficiency in mice. JAALAS. 2009;48(4):363-370.

Rasmussen S, Miller M, Filipski SB, Tolwani RJ. Cage change influences serum corticosterone and anxiety-like behaviors in the mouse. JAALAS. 2011;50(4):479-483.

Rezende NC, Lee M-Y, Monette S, et al. Rex1 (Zfp42) Null Mice Show Impaired Testicular Function, Abnormal Testis Morphology, and Aberrant Gene Expression. Dev Biol. 2011;356(2):370-382.

Ricart Arbona RJ, Lipman NS, Riedel ER, Wolf FR.  Treatment and Eradication of Murine Fur Mites: I. Toxicologic Evaluation of Ivermectin-Compounded Feed.  JAALAS. 2010; 49(5):564-570.

Ricart Arbona RJ, Lipman NS, Wolf FR. Murine Fur Mite Treatment and Eradication II: Diagnostic Considerations. JAALAS. 2010;49(5):583-587.

Ricart Arbona RJ, Lipman NS, Wolf FR. Murine Fur Mite Treatment and Eradication III: Treatment of a Large Mouse Colony with Ivermectin-Compounded Feed. JAALAS. 2010;49(5):633-637.

Roble GS, Boteler W, Riedel E, Lipman NS.  Total IgE as a Serodiagnostic Marker to Aid Murine Fur Mite Detection.  JAALAS. 2012; 51(2):199-208.

Roble GS, Gillespie V, Lipman NS.  Infectious Disease Survey of Mus musculus from Pet Stores in New York City.   JAALAS. 2012;5 (1):37-41.

Roble GS, Lingenhol NM, Baker B, Wilkerson A, Tolwani RJ. A comprehensive laboratory animal facility pandemic response plan. JAALAS. 2010;49(5):623-632.

Roepke TK, Purtell K, King EC, La Perle KM, et al. Targeted deletion of Kcne2 causes gastritis cystica profunda and gastric neoplasia. PLoS One. 2010;5(7):e11451

Ruggiero A, Brader P, Serganova I, Zanzonico P, Cai S, Lipman NS, Hricak H, Blasberg HG. Different strategies for reducing intestinal background radioactivity associated with imaging HSV1-tk expression using established radionuclide probes. Mol Imaging. 2010; 9(1):47-58.

Santos EB, Yeh R, Lee J, Nikhamin Y, Punzalan B, Punzalan B, La Perle K, et al. Sensitive in vivo imaging of T cells using a membrane-bound Gaussia princeps luciferase. Nat Med. 2009 Mar;15(3):338-344.

Schoellnast H, Monette S, Ezell PC, et al. Acute and subacute effects of irreversible electroporation on nerves: experimental study in a pig model. Radiology. 2011; 260(2):421-427.

Schoellnast H, Monette S, Ezell PC, et al. Irreversible Electroporation Adjacent to the Rectum: Evaluation of Pathological Effects in a Pig Model. Cardiovasc Intervent Radiol. 2013;36(1):213-220. 

Schoellnast H, Monette S, Ezell PC, et al. The Delayed Effects of Irreversible Electroporation Ablation on Nerves. Eur Radiol. 2013;23(2):375-380. 

Schoellnast H, Monette S, Ezell PC, et al. Interstitial laser-induced thermotherapy of the lung: evaluation of the influence of ablation continuity on ablation size in a swine model. Cancer Imaging. 2013;13:8-13.

Servais E, Colovos C, White JR, Sadelain M. Animal models and molecular imaging tools to investigate lymph node metastases.  J Molec Med. 2011;89(8):753-769. 

Shen Y, La Perle KM, Levy DE, et al. Reduced STAT3 activity in mice mimics clinical disease syndromes.  Biochem Biophys Res Commun. 2005;330(1):305-9.

Sondhi D, Johnson L, Purpura K, Monette S, et al. Long-Term Expression and Safety of Administration of AAVrh.10hCLN2 to the Brain of Rats and Nonhuman Primates for the Treatment of Late Infantile Neuronal Ceroid Lipofuscinosis. Hum Gene Ther Methods. 2012;23(5):324-335.

Srimathveeravalli G, Kim C, Petrisor D, Ezell P, Coleman J, Hricak H, Solomon SB, Stoianovici D MRI-safe robot for targeted transrectal prostate biopsy: animal experiments. BJU Int. 2014 Jun;113(6):977-985

Stracker TH, Couto SS, Cordon-Cardo C, et al. Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage. Mol Cell. 2008;31(1):21-32.

Stracker TH, Morales M, Couto SS, et al. The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex. Nature. 2007;447(7141):218-221.

Thurlow R, Arriola, R, Stoll C, Lipman NS. Evaluation of a flash disinfection process for surface disinfection of gamma-irradiated feed packaging. JAALAS. 2007;46(4):46-49.

Traslavina RP, King EJ, Loar AS, Riedel ER, Garvey MS, Ricart Arbona RJ, Wolf FR, Couto SS. Euthanasia by CO₂ inhalation affects potassium levels in mice. JAALAS. 2010;49(3):316-322. 

Veugelers M, Wilkes D, Burton K, McDermott DA, Song Y, Goldstein MM, La Perle K, et al. Comparative PRKAR1A genotype-phenotype analyses in humans with Carney complex and prkar1a haploinsufficient mice. Proc Natl Acad Sci U S A. 2004;101(39):14222-14227. 

Whipps CM, Lieggi C, Wagner R. Mycobacteriosis in Zebrafish colonies. ILAR J. 2012;53(2):95-105. 

Wimmer T, Srimathveeravalli G, Gutta N, Ezell P, Monette S, Maybody M, Erinjery J, Durack J, Coleman J, Solomon S. Planning Irreversible Electroporation in the Porcine Kidney: Are Numerical Simulations Reliable for Predicting Empiric Ablation Outcomes? CardioVascular and Interventional Radiology. May 2014.

Xiong X, Chorzalska A, Dubielecka PM, White JR, Vedvyas Y, Hedvat CV, Haimovitz-Friedman A, Koutcher JA, Reimand J, Bader GD, Sawicki JA, Kotula L. Disruption of Abi1/Hssh3bp1 expression induces prostatic intraepithelial neoplasia in the conditional Abi1/Hssh3bp1 KO mice. Oncogenesis. 2012; 1(9): e26.

Book Chapters

Burr HR, Palluch LR, Roble G, Lipman NS. Hamsters: Parasitic diseases. In: Suckow MA, Stevens KA, Wilson RP, eds. The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents. 1st ed. London, UK: Academic Press; 2012:839-866.

Cassano A, Rasmussen S, Wolf FW. Hamsters: Viral diseases. In: Suckow MA, Stevens KA, Wilson RP, eds. The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents. 1st ed. London, UK: Academic Press; 2012:821-837.

Lipman NS. Rat-Bite Fevers. In: Schlossberg D, ed. Current Therapy of Infectious Disease. 2nd edPhiladelphia, PA: Mosby-Yearbook, Inc; 2000:539-541. 

Lipman NS.  Design and Management of Research Facilities for Mice. In: Fox JG, et al, eds. The Mouse in Biomedical Research, vol III: Normative Biology, Immunology and Husbandry. Orlando, FL: Academic Press; 2007:271-319.

Lipman NS. Rat-Bite Fevers. In: Schlossberg D, ed. Clinical Infectious Disease. 3rd ed. New York, NY: Cambridge University Press; 2008:1039-1041.

Lipman NS. Rodent Facilities and Caging Systems. In: Hessler JR, Lehner NDM, eds, Planning and Designing Research Animal Facilities. San Diego, CA: Elsevier Inc; 2009:265-288.

Lipman NS, Marini RP, Flecknell PA. Anesthesia and analgesia in rabbits. In: Fish RF, et al, eds, Anesthesia and Analgesia in Laboratory Animals. 2nd ed. San Diego, CA: Elsevier Inc; 2008:299-334.

Lipman NS, Perkins SE. Inspection of individual laboratories. In: Murthy S, et al, eds. Institutional Animal Care and Use Handbook. Boca Raton, FL: CRC Press; 2000:419-429.

Lipman NS, Perkins SE. Factors that may influence animal research. In: Fox JG, et al, eds. Laboratory Animal Medicine. 2nd ed. Orlando, FL: Academic Press; 2002;1143-1185.

Perkins SE, Lipman NS Inspection of surgery areas. In: Murthy S, et al, eds. Institutional Animal Care and Use Handbook. Boca Raton, FL: CRC Press; 2000:431-436.


Lipman NS, Henderson K, Shek W. False negative results using RT-PCR for detection of lactate dehydrogenase-elevating virus in a tumor cell line. Comp Med. 2000;50(3):255-256.

Lipman NS, Perkins SE. Macroenvironmental relative humidity and bedding in isolator cages. Contemp Top Lab Anim Sci. 2000;39(6):7.