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B

Pictured: Renier J. Brentjens

Brentjens, Renier J.

Memorial Hospital Research Laboratories

Physician-scientist Renier Brentjens develops novel immunotherapies for leukemias and lymphomas.

C

Pictured: Jorge A. Carrasquillo

Carrasquillo, Jorge A.

Memorial Hospital Research Laboratories

Physician-scientist Jorge Carrasquillo focuses on the development of targeted radioimmunotherapy drugs.

Cheung, Nai-Kong V.

Memorial Hospital Research Laboratories

Physician-scientist Nai-Kong Cheung focuses on engineering of antibodies and immune cells to treat solid tumors in children.

D

Pictured: Samuel Danishefsky

Danishefsky, Samuel

Molecular Pharmacology & Chemistry Program

Samuel Danishefsky investigates the synthesis of antitumor natural products and of fully synthetic carbohydrate-based vaccines.

DeMatteo, Ronald

Memorial Hospital Research Laboratories

Physician-scientist Ronald DeMatteo focuses on strategies to reduce immune subversion in gastrointestinal stromal tumor and liver cancer and on immunobiology in liver cancer.

Pictured: Liang Deng

Deng, Liang

Memorial Hospital Research Laboratories

Physician-scientist Liang Deng studies poxvirus interface with the immune system and the development of poxviruses as oncolytic and immunotherapy for cancers.

H

Pictured: Alan Houghton

Houghton, Alan

Immunology Program

Cancer immunologist Alan Houghton studies the immune response to cancer, immune recognition of self and mutated molecules, and development of new immunotherapies.

Pictured: Katharine C. Hsu

Hsu, Katharine C.

Memorial Hospital Research Laboratories

Physician-scientist Katharine Hsu studies the biology of human natural killer cells and how they contribute to disease processes.

L

Livingston, Philip O.

Memorial Hospital Research Laboratories

Physician-scientist Philip Livingston studies tumor vaccinology, including approaches to augmenting the antibody and T cell response to defined cancer antigens.

O

Pictured: Richard O'Reilly

O'Reilly, Richard J.

Immunology Program

Physician-scientist Richard O'Reilly investigates the genetic disparities and cellular interactions between donor and host that affect allogeneic hematopoietic cell transplantation.

S

Scheinberg, David A.

Chair, Molecular Pharmacology & Chemistry Program, SKI

Molecular Pharmacology & Chemistry Program

Molecular Pharmacology and Chemistry Program Chair David Scheinberg focuses on the discovery and development of novel, specific immunotherapeutic agents and targeted nanodevices for cancer therapy.

W

Pictured: Jedd Wolchok

Wolchok, Jedd D.

Immunology Program

Physician-scientist Jedd Wolchok investigates novel approaches for cancer immunotherapy and mechanisms of tumor cell–immune cell interactions.

Y

Pictured: James Young

Young, James W.

Memorial Hospital Research Laboratories

Physician-scientist James Young studies innate and adaptive immunity against tumors and viruses stimulated by human dendritic cells.

allogeneic (A-loh-jeh-NAY-ik)

Taken from different individuals of the same species. Also called allogenic.

Source: The National Cancer Institute's Dictionary of Cancer Terms
(http://www.cancer.gov/dictionary)

antibody (AN-tee-BAH-dee)

A protein made by plasma cells (a type of white blood cell) in response to an antigen (a substance that causes the body to make a specific immune response). Each antibody can bind to only one specific antigen. The purpose of this binding is to help destroy the antigen. Some antibodies destroy antigens directly. Others make it easier for white blood cells to destroy the antigen.

Source: The National Cancer Institute's Dictionary of Cancer Terms
(http://www.cancer.gov/dictionary)

antitumor (AN-tee-TOO-mer)

Having to do with stopping abnormal cell growth.

Source: The National Cancer Institute's Dictionary of Cancer Terms
(http://www.cancer.gov/dictionary)

cancer (KAN-ser)

A term for diseases in which abnormal cells divide without control and can invade nearby tissues. Cancer cells can also spread to other parts of the body through the blood and lymph systems. There are several main types of cancer. Carcinoma is a cancer that begins in the skin or in tissues that line or cover internal organs. Sarcoma is a cancer that begins in bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. Leukemia is a cancer that starts in blood-forming tissue such as the bone marrow, and causes large numbers of abnormal blood cells to be produced and enter the blood. Lymphoma and multiple myeloma are cancers that begin in the cells of the immune system. Central nervous system cancers are cancers that begin in the tissues of the brain and spinal cord. Also called malignancy.

Source: The National Cancer Institute's Dictionary of Cancer Terms
(http://www.cancer.gov/dictionary)

cell (sel)

The individual unit that makes up the tissues of the body. All living things are made up of one or more cells.

Source: The National Cancer Institute's Dictionary of Cancer Terms
(http://www.cancer.gov/dictionary)

donor (DOH-ner)

In medicine, a person who gives blood, cells, tissue, or an organ for use in another person, such as in a blood transfusion or an organ transplant.

Source: The National Cancer Institute's Dictionary of Cancer Terms
(http://www.cancer.gov/dictionary)

gastrointestinal (GAS-troh-in-TES-tih-nul)

Refers to the stomach and intestines. Also called GI.

Source: The National Cancer Institute's Dictionary of Cancer Terms
(http://www.cancer.gov/dictionary)

genetic (jeh-NEH-tik)

Inherited; having to do with information that is passed from parents to offspring through genes in sperm and egg cells.

Source: The National Cancer Institute's Dictionary of Cancer Terms
(http://www.cancer.gov/dictionary)

immune response (ih-MYOON reh-SPONTS)

The activity of the immune system against foreign substances (antigens).

Source: The National Cancer Institute's Dictionary of Cancer Terms
(http://www.cancer.gov/dictionary)

immune system (ih-MYOON SIS-tem)

The complex group of organs and cells that defends the body against infections and other diseases.

Source: The National Cancer Institute's Dictionary of Cancer Terms
(http://www.cancer.gov/dictionary)

immunity (ih-MYOO-nih-tee)

The condition of being protected against an infectious disease. Immunity can be caused by a vaccine, previous infection with the same agent, or by transfer of immune substances from another person or animal.

Source: The National Cancer Institute's Dictionary of Cancer Terms
(http://www.cancer.gov/dictionary)

immunology (IH-myoo-NAH-loh-jee)

The study of the body's immune system.

Source: The National Cancer Institute's Dictionary of Cancer Terms
(http://www.cancer.gov/dictionary)

immunotherapy (IH-myoo-noh-THAYR-uh-pee)

Treatment to boost or restore the ability of the immune system to fight cancer, infections, and other diseases. Also used to lessen certain side effects that may be caused by some cancer treatments. Agents used in immunotherapy include monoclonal antibodies, growth factors, and vaccines. These agents may also have a direct antitumor effect. Also called biological response modifier therapy, biological therapy, biotherapy, and BRM therapy.

Source: The National Cancer Institute's Dictionary of Cancer Terms
(http://www.cancer.gov/dictionary)

liver (LIH-ver)

A large organ located in the upper abdomen. The liver cleanses the blood and aids in digestion by secreting bile.

Source: The National Cancer Institute's Dictionary of Cancer Terms
(http://www.cancer.gov/dictionary)

liver cancer (LIH-ver KAN-ser)

Primary liver cancer is cancer that forms in the tissues of the liver. Secondary liver cancer is cancer that spreads to the liver from another part of the body.

Source: The National Cancer Institute's Dictionary of Cancer Terms
(http://www.cancer.gov/dictionary)

oncolytic

Refers to viruses that kill cancer cells more often than they kill normal cells.

Source: The National Cancer Institute's Dictionary of Cancer Terms
(http://www.cancer.gov/dictionary)

pharmacology (FAR-muh-KAH-loh-jee)

The study of the origin, chemistry, and uses of drugs and their effects on the body.

Source: The National Cancer Institute's Dictionary of Cancer Terms
(http://www.cancer.gov/dictionary)

radioimmunotherapy (RAY-dee-oh-IH-myoo-noh-THAYR-uh-pee)

A type of systemic radiation therapy in which a radioactive substance is linked to an antibody that locates and kills tumor cells when injected into the body.

Source: The National Cancer Institute's Dictionary of Cancer Terms
(http://www.cancer.gov/dictionary)

response (reh-SPONTS)

In medicine, an improvement related to treatment.

Source: The National Cancer Institute's Dictionary of Cancer Terms
(http://www.cancer.gov/dictionary)

stromal tumor (STROH-mal TOO-mer)

A tumor that arises in the supporting connective tissue of an organ.

Source: The National Cancer Institute's Dictionary of Cancer Terms
(http://www.cancer.gov/dictionary)

synthetic (sin-THEH-tik)

Having to do with substances that are man-made instead of taken from nature.

Source: The National Cancer Institute's Dictionary of Cancer Terms
(http://www.cancer.gov/dictionary)

therapy (THAYR-uh-pee)

Treatment.

Source: The National Cancer Institute's Dictionary of Cancer Terms
(http://www.cancer.gov/dictionary)

transplantation (tranz-plan-TAY-shun)

A surgical procedure in which tissue or an organ is transferred from one area of a person’s body to another area, or from one person (the donor) to another person (the recipient).

Source: The National Cancer Institute's Dictionary of Cancer Terms
(http://www.cancer.gov/dictionary)

tumor (TOO-mer)

An abnormal mass of tissue that results when cells divide more than they should or do not die when they should. Tumors may be benign (not cancer), or malignant (cancer). Also called neoplasm.

Source: The National Cancer Institute's Dictionary of Cancer Terms
(http://www.cancer.gov/dictionary)