Biostatistics: Statistical Methods for the Analysis of Ribosome Profiling Data

During translation messenger RNA produced by transcription is decoded by ribosomes to produce specific polypeptides.  Recently, a second generation sequencing methodology was developed called ribosomal profiling that measures the positions and counts of ribosomes. When combined with corresponding mRNA sequencing data, ribosomal data can give insights into translational efficiency.  I will discuss issues that arise when analyzing such data, including normalization and testing hypotheses.  

This is joint work with Barry Taylor and Richard Olshen.

Event Information

Date & Time(s)
Wednesday, September 25, 2013, 4:00 PM – 5:00 PM
Sponsor(s)

Biostatistics Seminar Series
Department of Epidemiology and Biostatistics
Memorial Sloan Kettering Cancer Center

Speaker(s)

Adam B. Olshen, PhD
Professor in Residence
Department of Epidemiology and Biostatistics
University of California, San Francisco
School of Medicine

Location Information

Memorial Sloan Kettering Cancer Center
307 East 63rd Street
3rd Floor Conference Room
New York, NY 10065