Biostatistics: Statistical Methods for Next-Generation Sequencing Data

Rapid advances in sequencing technologies set the stage for large-scale medical sequencing efforts to assess the importance of rare variants in complex diseases. The low frequency and expected large number of such variants pose difficulties for the analysis of these data. We discuss several statistical strategies for association testing with rare variants, and show applications to a study on autism. Implications to study designs will also be discussed.

Event Information

Date & Time(s)
Wednesday, January 26, 2011, 4:00 PM
Speaker(s)

Iuliana Ionita-Laza
Department of Biostatistics
Columbia University

Contact Information

Address

307 East 63rd Street, 3rd Floor Conference Room