Yvonne Bombard

Office Phone:

646-888-4475

Office Fax:

646-227-7102

E-mail:

bombardy@mskcc.org

Education:

University of British Columbia, University of Toronto, Yale University

Dr. Bombard's research focuses on the health outcomes and policy implications of translating personalized genomic technologies into healthcare. Dr. Bombard conducts mixed methods research that assesses the impact of genomic screens and tests on patients, providers, population health, and health services. With colleagues in Clinical Genetics, Psychiatry and Behavioral Sciences, and Health Policy and Outcomes, she is assessing the health outcomes and health service implications of integrating whole-genome sequencing into clinical care. With colleagues in Canada, Dr. Bombard is evaluating the clinical utility of a gene-expression profile test for recurrence risk (called OncotypeDx) in treatment decision-making for breast cancer. Dr. Bombard also conducts public engagement research to advance newborn screening policy and health technology assessment. Dr. Bombard has been recognized for her PhD research on genetic discrimination in Huntington disease, which has translated into policy developments in Canada, and into international clinical practice guidelines.

Publications by Yvonne Bombard

Bombard Y, Veenstra G, Friedman JM, Creighton S, Currie L, Paulsen JS, Bottorff JL, Hayden MR; Canadian Respond-HD Collaborative Research Group. Perceptions of genetic discrimination among persons at risk for Huntington’s disease: a cross-sectional survey. British Medical Journal.2009;338:b2175.

Editorials: British Medical Journal; 2009;338:[b1281]
Nature Reviews Neurology; 2009 Oct;5(10):525-6.
Media coverage: Forbes, ABC, MSN, CBC, the Globe Mail, Toronto Star, CTV, and others.
Publication Award from the Canadian Institutes of Health Research (CIHR)

Bombard Y, Miller FA, Hayeems RZ, Avard D, Knoppers BM, Cornell MC, Borry P. The expansion of newborn screening: is reproductive benefit an appropriate pursuit? Nature Reviews Genetics. 2009 Oct;10(10):666-7.

Editorial: Nature Genetics; 2010 Oct;42(10):811.

Bombard Y, Miller FA. Reproductive benefit through newborn screening: Preferences, policy and ethics. European Journal of Human Genetics. 2012 May;20(5):486-7.

Bombard Y, Miller FA, Hayeems RZ, Carroll JC, Avard D, Allanson J, Axler R, Bytautas J, Chakraborty P, Giguere Y, Little J, Wilson B. Citizens’ values regarding research with stored samples from newborn screening. Pediatrics. 2012 Feb;129(2):239-47.

Editorial: Pediatrics. 2012 Feb; 129(2).

Bombard Y, Offit K, Robson ME. Risks to relatives in genomic research: a duty to warn? American Journal of Bioethics. 2012 Oct;12(10):12-4.

Full List of Publications

Hayeems RZ, Miller FA, Bombard Y, Carroll JC, Avard D, Allanson J, Axler R, Bytautas J, Chakraborty P, Giguere Y, Little J, Wilson B. Expectations and values about expanded newborn screening: A public engagement study. Health Expectations. (In press)
MacLeod R, Tibben A, Frontali M, Evers Kiebooms G, Jones A, Martinez-Descales A, Roos R, Editorial Committee, and the EHDN Genetic Testing and Counselling working group*. Recommendations for the predictive genetic test in Huntington’s disease. Clinical Genetics. (In Press)
- (* Chair of the discrimination sub-group of the European Huntington disease Network Working Group on Genetic Testing and Counselling, responsible for updates to the international genetic testing guidelines.)
Bombard Y, Offit K, Robson ME. Risks to relatives in genomic research: a duty to warn? American Journal of Bioethics 2012 Oct;12(10):12-4.
Bombard Y, Otlowski M, Taylor S. Genetic discrimination: international perspectives. Annual Review of Genomics and Human Genetics. 2012 Sep 22;13:433-54.
Bombard Y, Miller FA. Reproductive benefit through newborn screening: preferences, policy and ethics. European Journal of Human Genetics. 2012 May;20(5):486-7.
Bombard Y, Miller FA, Hayeems RZ, Carroll JC, Avard D, Wilson BJ, Little J, Bytautas JP, Allanson J, Axler R, Giguere Y, Chakraborty P. Citizens' values regarding research with stored samples from newborn screening in Canada. Pediatrics. 2012 Feb;129(2):239-47.
- Editorial in: Pediatrics. 2012 Feb;129(2):365-6
Bombard Y, Palin J, Friedman JM, Veenstra G, Creighton S, Bottorff J, Hayden MR and the Canadian Respond-HD Collaborative Research Group. Beyond the patient: The broader impact of discrimination among individuals at risk of Huntington disease. American Journal of Medical Genetics. 2012 Mar;159B(2):217-226.
Bombard Y, Miller FA, Hayeems RZ, Wilson BJ, Carroll JC, Paynter M, Little J, Allanson J, Bytautas JP, Chakraborty P. Healthcare providers’ views on pursuing reproductive benefit through newborn screening: The case of sickle cell disorders. European Journal of Human Genetics. 2012 May;20(5):498-504.
- Editorial: European Journal of Human Genetics; May;20(5):484-5..
Culyer AJ, Bombard Y. An equity framework for health technology assessments. Journal of Medical Decision Making. 2012 May-Jun;32(3):428-41.
Bombard Y, Cox SM, Semaka A. When they hear what we say: ethical challenges in presenting research findings to the Huntington disease community. Journal of Empirical Research on Human Research Ethics. 2011 Sep;6(3):47-54.
Bombard Y, Abelson J, Simeonov D, Gauvin FP. Eliciting ethical and social values in health technology assessment: A participatory approach. Social Science and Medicine.2011 Jul;73(1):135-44.
Bombard Y, Semaka A, Hayden MR. Adoption and communication of genetic risk: experiences in Huntington disease. Clinical Genetics. 2012 Jan;81(1):64-9.
Bombard Y, Palin J, Friedman JM, Veenstra G, Creighton S, Paulsen J, Bottorff J, Hayden MR; Canadian Respond-HD Collaborative Research Group. Factors associated with experiences of genetic discrimination among individuals at risk for Huntington’s disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2011 Jan;156B(1):19-27.
Bombard Y, Miller FA, Hayeems RZ, Avard D, Knoppers BM. Reconsidering reproductive benefit through newborn screening: a systematic review of guidelines on preconception, prenatal and newborn screening. European Journal of Human Genetics. 2010 Jul;18(7):751-60.
- Editorial: Nature Genetics; 2010 Oct;42(10):811
Erwin C, Williams JK, Juhl AR, Mengeling M, Mills JA, Bombard Y, Hayden MR, Quaid K, Shoulson I, Taylor S, Paulsen JS, and the I-RESPOND-HD Investigators of the Huntington Study Group. Perception, experience, and response to genetic discrimination in Huntington disease: the international RESPOND-HD study. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2010 Jul;153B(5):1081-93.
Williams JK, Erwin C, Juhl AR, Mengeling M, Mills JA, Bombard Y, Hayden MR, Quaid K, Shoulson I, Taylor S, Paulsen JS, and the I-RESPOND-HD Investigators of the Huntington Study Group. In their own words: reports of stigma and genetic discrimination by people at risk for Huntington disease in the International RESPOND-HD study. American Journal of Medical Genetics Part B: Psychiatric Genetics. 2010 Sep;153B(6):1150-9.
Miller FA, Hayeems RZ, Bombard Y, Little J, Carroll JC, Wilson B, Allanson J, Paynter M, Bytautas J, Christensen R. Clinical obligations and public health programmes: healthcare provider reasoning about managing the incidental results of newborn screening. Journal of Medical Ethics. 2009 Oct;35(10):626-34.
Bombard Y, Miller FA, Hayeems RZ, Avard D, Knoppers BM, Cornell MC, Borry P. The expansion of newborn screening: is reproductive benefit an appropriate pursuit? Nature Reviews Genetics. 2009 Oct;10(10):666-7.
- Editorial: Nature Genetics; 2010 Oct;42(10):811.
Bombard Y, Veenstra G, Friedman JM, Creighton S, Currie L, Paulsen JS, Bottorff JL, Hayden MR; Canadian Respond-HD Collaborative Research Group. Perceptions of genetic discrimination among persons at risk for Huntington’s disease: a cross-sectional survey. British Medical Journal.2009;338:b2175.
- Editorials: British Medical Journal;2009;338:[b1281] 
  Nature Reviews Neurology; 2009 Oct;5(10):525-6.
- Media coverage: Forbes, ABC, MSN, CBC, the Globe Mail, Toronto Star, CTV, and others. 
- Publication Award from the Canadian Institutes of Health Research (CIHR)
Bombard Y, Penziner E, Suchowersky O, Guttman M, Paulsen JS, Bottorff JL, Hayden MR. Engagement with genetic discrimination: concerns and experiences in the context of Huntington disease. European Journal of Medical Genetics. 2008 Mar;16(3):279-89.
- Publication Award from the Canadian Institutes of Health Research
Bombard Y, Penziner E, Decolongon J, Klimek M, Creighton S, Suchowersky O, Guttman M, Paulsen J, Bottorff JL, Hayden MR. Managing genetic discrimination: Strategies used by individuals found to have the Huntington disease mutation. Clinical Genetics. 2007 Mar; 71(3):220-31.
Penziner E, Williams JK, Erwin C, Bombard Y, Wallis A, Beglinger JL, Hayden MR, Paulsen JS. Perceptions of discrimination among persons who have undergone predictive testing for Huntington disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2007 Apr 5;147(3):320-5.
Hayden, MR., Bombard, Y. Psychosocial effects of predictive testing for Huntington disease. Advances in Neurology. 2005;96:226-39. Review.
Harper PS, Gever S, de Wert G, Creighton S, Bombard Y, Hayden MR. Genetic testing and Huntington disease: issues of employment. Lancet Neurology. 2004 Apr;3(4): 249-252.

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