Geoffrey Beene Cancer Research Center: 2013 Geoffrey Beene Shared Resources Awards

The following investigators were awarded Geoffrey Beene Cancer Research Center shared resources funds in 2012:

Elisa DeStanchina
Antitumor Assessment Core Facility

Project Abstract: To initiate first-in-human clinical trials, the FDA requires that animal safety studies be conducted in accordance with federal regulations for Good Laboratory Practices (GLP). In the past five years alone, Memorial Sloan Kettering investigators have developed more than 20 investigational new drugs (INDs), including biologics, radiopharmaceuticals, and small molecule drugs, which have been cleared by the FDA for clinical trials at Memorial Sloan Kettering The Antitumor Assessment Facility conducted IND-enabling safety studies for more than half of these studies in a GLP-like manner. However, similar future studies will have to be conducted under strict GLP conditions. Currently, no facility exists for conducting GLP-compliant studies at Memorial Sloan Kettering; therefore, the only option available for investigators developing novel agents is to contract GLP safety studies to an outside vendor (CRO). Drug development efforts with CROs are extremely costly, frequently delayed, and often suffer difficulties in method development, technology transfer, and initial characterization of novel agents. Thus, to maintain a competitive translational research program, Memorial Sloan Kettering needs to develop internal resources to conduct GLP studies in a more cost- and time-effective way. The proposed resource will enable investigators to conduct GLP-compliant animal safety studies onsite at Memorial Sloan Kettering, thereby streamlining preclinical development and reducing costs.

Gunnar Ratsch
Computational Biology

Project Abstract: The rapid increase in speed and decrease in cost of DNA sequencing have started a revolution in genomics. While data generation is now quick and cost-effective, data transfer and storage issues currently prevent the effective use of many new data-sequencing resources . At present, researchers may lose precious time, bandwidth, and disk space by downloading and storing large-scale and commonly utilized data resources. The establishment of a one-petabyte (1,000,000-gigabytes) local data storage server will solve these issues for many Memorial Sloan Kettering investigators across departments by providing fast and convenient access to insight-enabling data. The resources we have targeted include The Cancer Genome Atlas, ENCODE, The 1000 Genomes Project, The Human Microbiome Project, and others.