Pioglitazone (Actos®) is a drug used to treat type II diabetes. It also has the potential to reduce the risk of oral precancerous lesions from progressing to cancer.
In this study, researchers want to determine the effects of pioglitazone on oral precancers and the risk of developing oral cancer. Patients will be randomly assigned to receive pioglitazone or a placebo. Pioglitazone is a capsule that is taken orally.