Cetuximab is a chemotherapy drug used to treat head and neck cancer and advanced colorectal cancer. Cetuximab often causes a painful and itchy acne-like rash on the face and body. In some patients, the rash can become severe and uncomfortable enough that their cetuximab dose may need to be reduced or even temporarily withheld, potentially impacting the effectiveness of their cancer treatment.
In this study, researchers want to assess the ability of a topical medication (dapsone gel) to prevent the acne-like rash of cetuximab in patients with cancer.
Dapsone gel is already approved to treat acne. Patients will be randomly assigned to apply dapsone gel to the left or right side of the face and chest, and a moisturizer (placebo) to the other side of the face and chest. All patients will also take oral antibiotics, as this has previously been shown in clinical trials to be useful for treating the acne-like rash caused by cetuximab.