An infusion of stem cells from a donor — an allogeneic stem cell transplant — is one way of treating hematologic cancers and disorders. One potential complication of stem cell transplantation is graft-versus-host disease (GvHD). GvHD is caused when cells from the donor view the recipient’s cells as foreign, resulting in symptoms such as rash, diarrhea, nausea, and vomiting, among others.
Removing the T cells (T-cell depletion) from the donor’s stem cell transplant lowers the risk of GvHD. In this study, researchers are assessing an investigational method of T-cell depletion called the CliniMACS system in patients with acute lymphoblastic leukemia (ALL), acute and chronic myelogenous leukemia (AML and CML), non-Hodgkin lymphoma, multiple myeloma, a high-risk form of myelodysplastic syndrome, and other serious diseases of the blood-forming cells.
Patients in this study will receive one of three treatments to treat their cancers and prepare them for a T-cell depleted transplant using CliniMACS. The treatments each involve a combination of chemotherapy drugs, with or without total body irradiation. Researchers are also evaluating how well the blood stem cells grow in the patient’s body, and whether CliniMACS T-cell depleted transplants can prevent GvHD.