Genomic analysis of human and mouse gliomas and medulloblastomas.
Identification and characterization of tumor suppressors in glioblastoma and breast cancer.
Regulation of growth factor signaling networks in cancer.
The role of transcription factors that are critical for prostate cancer development.
The molecular mechanisms of cell death and their implications in tumorigenesis and cancer therapy.
Genetic and epigenetic mechanisms of transcriptional regulation by oncogenic transcription factors in GIST and other solid tumors.
Pathogenesis of thyroid cancer and the role of oncogenic kinases.
Development of novel therapeutics targeting cancer cell proliferation and establishment of a translational kidney cancer program.
Molecular pathogenesis of brain tumors, particularly high-grade gliomas.
Molecular pathogenesis of sarcomas, lung cancer, and mesothelioma.
Investigation of genetic basis of hematopoietic malignancies.
Signal transduction alterations in primary brain tumors.
Identification and characterization of molecular pathways that regulate normal and malignant stem cells in the hematopoietic system.
Molecularly targeted cancer therapy.
Human oncology and pathogenesis, genomics, oncogenes and tumor suppressors, cancer therapeutics, and clinical trials.
