Our studies in cancer biology and pediatric oncology are focused on cellular plasticity, a phenomenon that relates both to the fundamental mechanisms of cancer pathogenesis and to the development of improved rational therapies. Detailed information about our research is available at http://alexkentsis.net.

Publications

Mansour MR, Reed C, Eisenberg AR, Tseng JC, Twizere JC, Daakour S, Yoda A, Rodig SJ, Tal N, Shochat C, Berezovskaya A, DeAngelo DJ, Sallan SE, Weinstock DM, Izraeli S, Kung AL, Kentsis A, Look AT. Targeting oncogenic interleukin-7 receptor signalling with N-acetylcysteine in T cell acute lymphoblastic leukaemia. British Journal of Haematology, 2014.

Kentsis A, Reed C, Rice KL, Sanda T, Rodig SJ, Tholouli E, Christie A, Valk PJ, Delwel R, Ngo V, Kutok JL, Dahlberg SE, Moreau LA, Byers RJ, Christensen JG, Vande Woude G, Licht JD, kung AL, Staudt LM, Look AT. Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia. Nature Med 18: 1118-22, 2012.

Kentsis A, Lin YY, Kurek K, Calicchio M, Wang YY, Monigatti F, Campagne F, Lee R, Horwitz B, Steen H, Bachur R. Discovery and validation of urine markers of acute pediatric appendicitis using high accuracy mass spectrometry. Ann Emerg Med 55(1):62-70, 2010.

Kentsis A, Topisirovic I, Culjkovic B, Shao L, Borden KL. Ribavirin suppresses eIF4E mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap. Proc Natl Acad Sci 101(52):18105-18110, 2004.

Kentsis A, Gordon RE, Borden KL. Control of biochemical reactions through supramolecular RING domain self-assembly. Proc Natl Acad Sci 99(24):15404-15409, 2002.

Kentsis A, Sosnick TR. Trifluoroethanol promotes helix formation by destabilizing backbone exposure: desolvation rather than native hydrogen bonding defines the kinetic pathway of dimeric coiled coil folding. Biochemistry 37(41):14613-14622, 1998.

Office phone:
1-646-888-2593; Assistant: Pascale Presendor, 1-646-888-2194
Laboratory phone:
1-646-888-3557
Selected Achievements

Scholar Award, American Society of Hematology (2013)

Career Award for Medical Scientists, Burroughs Wellcome Fund (2013)

Young Investigator Award, American Society for Pediatric Hematology/Oncology (2013)

Young Investigator Award, Alliance for Clinical Trials in Oncology (2012)

Research Award, Society of Pediatric Research (2009)

Pediatric Hematology-Oncology Fellowship, Dana-Farber Cancer Institute and Boston Children’s Hospital, Harvard Medical School

Residency in Pediatrics, Boston Children’s Hospital, Harvard Medical School

MD and PhD, Mount Sinai School of Medicine and New York University

AB and SM, University of Chicago