Education and Training
Postdoctoral Research Fellow, Skirball Institute, NYU School of Medicine and Sloan-Kettering Institute, Joyner lab
Ph.D. thesis, Developmental Biology, University Paris 7
“Cellular basis of hair follicle morphogenesis in the mouse. A clonal analysis using a method of temporal induction of clones.”
Paris 7 University/Pasteur Institute, Unit of molecular biology of development (supervisor: Pr. Jean-Francois Nicolas).
Master, Molecular and Cellular Biology of Development, University Paris 7/Pasteur Institute
BS, Biochemistry, University Paris 7
I am interested in morphogenesis and how cell behaviors, that is cell proliferation, cell movements, lineage allocation and differentiation, are coordinated in order to give rise to a three-dimensionally shaped organ. The cerebellum is a very interesting model to study these questions. It has a relatively simple cellular organization that comprises several cell types arranged in specific layers, however it has a rather complex 3D organization: anatomically, the cerebellum is divided into a central vermis and two lateral hemispheres along the medial-lateral axis, and is divided into lobules along the anterior-posterior axis; furthermore, gene expression domains provide another level of organization along the medial-lateral and anterior-posterior axes. Interestingly, mutants for Engrailed genes display alteration of anatomical and genetic domains organization. My project is to describe how cells are spatially allocated relatively to the anatomical and genetic landmarks during cerebellum morphogenesis and to understand the roles of Engrailed genes in the coordination of these cell behaviors.