Our lab studies cancer-associated microRNAs (miRNAs). MiRNAs constitute a family of small non-coding RNAs that modulate the expression of protein coding genes in a sequence-specific manner. They are found in all bilateria and account for a significant fraction of vertebrate genes. The human genome, for example, contains over five hundred miRNAs. Despite the intense scrutiny they have recently received, the exact biological function of most miRNAs is still largely unknown.