Anna-Katerina Hadjantonakis, PhD

Regenerative medicine holds enormous promise for patients with degenerative diseases and other conditions. But the foundations for safe and effective treatment depend on a deep understanding of the mechanisms of cell lineage specification, cellular reprogramming and the optimal environment for maintaining the phenotypic stability of pluripotent cells, and the cell types that can be directed to differentiate from them. These foundations will, in large part, be defined through experimental investigation of factors regulating these processes during normal embryogenesis.

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Selected Achievements

Identification of Eomesodermin/Tbr2 as the critical transcription factor in the gene regulatory network directing anterior-posterior axis formation in the mouse

Linking of the formation of the embryonic endoderm with the establishment of left-right asymmetry within the early embryo

Demonstration of a lineage relationship between the extra-embryonic endoderm and the somatic endoderm tissues of the embryo

First single-cell resolution live imaging study of pluripotent epiblast versus extra-embryonic endoderm cell lineage commitment within the inner cell mass (ICM) of the mouse embryo

Development of some of the first live-imaging reporters in mice, including reporters for singe-cell resolution and photoconvertible cell imaging

Kat Hadjantonakis

At Work: Developmental Biologist Anna-Katerina Hadjantonakis

Developmental biologist Kat Hadjantonakis works to gain insights into the critical events that direct the formation and shape of mammalian embryos.